Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

Jason Olejniczak; Viet Anh Nguyen Huu; Jacques Lux; Madeleine Grossman; Sha He; Adah Almutairi

doi:10.1039/c5cc06143a

Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

Jason Olejniczak, Viet Anh Nguyen Huu, Jacques Lux, Madeleine Grossman, Sha He, Adah Almutairi

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

Original language	English (US)
Pages (from-to)	16980-16983
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	95
DOIs	https://doi.org/10.1039/c5cc06143a
State	Published - Sep 28 2015

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c5cc06143a

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abstract = "We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.",

author = "Jason Olejniczak and {Nguyen Huu}, {Viet Anh} and Jacques Lux and Madeleine Grossman and Sha He and Adah Almutairi",

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AU - Olejniczak, Jason

AU - Nguyen Huu, Viet Anh

AU - Lux, Jacques

AU - Grossman, Madeleine

AU - He, Sha

AU - Almutairi, Adah

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015/9/28

Y1 - 2015/9/28

N2 - We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

AB - We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

Abstract

ASJC Scopus subject areas

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