Limiting inflammation - The negative regulation of NF-B and the NLRP3 inflammasome

Inna S. Afonina, Zhenyu Zhong, Michael Karin, Rudi Beyaert

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.

Original languageEnglish (US)
Pages (from-to)861-869
Number of pages9
JournalNature Immunology
Volume18
Issue number8
DOIs
StatePublished - Jul 19 2017
Externally publishedYes

Fingerprint

Inflammasomes
Inflammation
Autoimmune Diseases
Homeostasis
Pathology
Wounds and Injuries
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Limiting inflammation - The negative regulation of NF-B and the NLRP3 inflammasome. / Afonina, Inna S.; Zhong, Zhenyu; Karin, Michael; Beyaert, Rudi.

In: Nature Immunology, Vol. 18, No. 8, 19.07.2017, p. 861-869.

Research output: Contribution to journalReview article

Afonina, Inna S. ; Zhong, Zhenyu ; Karin, Michael ; Beyaert, Rudi. / Limiting inflammation - The negative regulation of NF-B and the NLRP3 inflammasome. In: Nature Immunology. 2017 ; Vol. 18, No. 8. pp. 861-869.
@article{74af32d15c8945e584d639c6a5e4c773,
title = "Limiting inflammation - The negative regulation of NF-B and the NLRP3 inflammasome",
abstract = "A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.",
author = "Afonina, {Inna S.} and Zhenyu Zhong and Michael Karin and Rudi Beyaert",
year = "2017",
month = "7",
day = "19",
doi = "10.1038/ni.3772",
language = "English (US)",
volume = "18",
pages = "861--869",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Limiting inflammation - The negative regulation of NF-B and the NLRP3 inflammasome

AU - Afonina, Inna S.

AU - Zhong, Zhenyu

AU - Karin, Michael

AU - Beyaert, Rudi

PY - 2017/7/19

Y1 - 2017/7/19

N2 - A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.

AB - A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer. Here, we discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-B pathway and the NLRP3 inflammasome. Understanding these negative regulatory mechanisms should facilitate the development of much-needed therapeutic strategies for treatment of inflammatory and autoimmune pathologies.

UR - http://www.scopus.com/inward/record.url?scp=85025814086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025814086&partnerID=8YFLogxK

U2 - 10.1038/ni.3772

DO - 10.1038/ni.3772

M3 - Review article

C2 - 28722711

AN - SCOPUS:85025814086

VL - 18

SP - 861

EP - 869

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 8

ER -