Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: The randomized MARLINA-T2D trial

Per Henrik Groop, Mark E. Cooper, Vlado Perkovic, Berthold Hocher, Keizo Kanasaki, Masakazu Haneda, Guntram Schernthaner, Kumar Sharma, Robert C. Stanton, Robert Toto, Jessica Cescutti, Maud Gordat, Thomas Meinicke, Audrey Koitka-Weber, Sandra Thiemann, Maximilian von Eynatten

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Aims: The MARLINA-T2D study (ClinicalTrials.gov, NCT01792518) was designed to investigate the glycaemic and renal effects of linagliptin added to standard-of-care in individuals with type 2 diabetes and albuminuria. Methods: A total of 360 individuals with type 2 diabetes, HbA1c 6.5% to 10.0% (48-86mmol/mol), estimated glomerular filtration rate (eGFR)≥30mL/min/1.73m2 and urinary albumin-to-creatinine ratio (UACR) 30-3000mg/g despite single agent renin-angiotensin-system blockade were randomized to double-blind linagliptin (n=182) or placebo (n=178) for 24weeks. The primary and key secondary endpoints were change from baseline in HbA1c at week 24 and time-weighted average of percentage change from baseline in UACR over 24weeks, respectively. Results: Baseline mean HbA1c and geometric mean (gMean) UACR were 7.8%±0.9% (62.2±9.6mmol/mol) and 126mg/g, respectively; 73.7% and 20.3% of participants had microalbuminuria or macroalbuminuria, respectively. After 24weeks, the placebo-adjusted mean change in HbA1c from baseline was -0.60% (-6.6mmol/mol) (95% confidence interval [CI], -0.78 to -0.43 [-8.5 to -4.7mmol/mol]; P<.0001). The placebo-adjusted gMean for time-weighted average of percentage change in UACR from baseline was -6.0% (95% CI, -15.0 to 3.0; P=.1954). The adverse-event profile, including renal safety and change in eGFR, was similar between the linagliptin and placebo groups. Conclusions: In individuals at early stages of diabetic kidney disease, linagliptin significantly improved glycaemic control but did not significantly lower albuminuria. There was no significant change in placebo-adjusted eGFR. Detection of clinically relevant renal effects of linagliptin may require longer treatment, as its main experimental effects in animal studies have been to reduce interstitial fibrosis rather than alter glomerular haemodynamics.

Original languageEnglish (US)
JournalDiabetes, Obesity and Metabolism
DOIs
StateAccepted/In press - 2017

Keywords

  • Antidiabetic drug
  • Clinical trial
  • Diabetic nephropathy
  • DPP-IV inhibitor
  • Glycaemic control
  • Linagliptin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Groop, P. H., Cooper, M. E., Perkovic, V., Hocher, B., Kanasaki, K., Haneda, M., Schernthaner, G., Sharma, K., Stanton, R. C., Toto, R., Cescutti, J., Gordat, M., Meinicke, T., Koitka-Weber, A., Thiemann, S., & von Eynatten, M. (Accepted/In press). Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: The randomized MARLINA-T2D trial. Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.13041