Linkage analysis with RFLPs in families with androgen resistance syndromes: evidence for close linkage between the androgen receptor locus and the DXS1 segment

Peter Wieacker, Jim Griffin III, Thomas Wienker, James M. Lopez, Jean D. Wilson, Meinert Breckwoldt

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Three families with androgen resistance syndromes - two with testicular feminization and one with Reifenstein syndrome - have been studied for linkage analysis. Using three cloned DNA sequences from the centromere region and the proximal long arm of the X chromosome (p8, pDP34, and S9, which define respectively the chromosomal segments DXS1, DXYS1, and DXS17), we found no recombination between the DXS1 locus and the mutant genes in the three families. Assuming that these disorders are the result of allelic mutations at the same locus for the androgen receptor, we can conclude that there is a close linkage between DXS1 and the androgen receptor locus, with a maximum lod score ž=3.5 at a recombination fraction θ=0.0 using the LIPED program (Ott 1974).

Original languageEnglish (US)
Pages (from-to)248-252
Number of pages5
JournalHuman genetics
Volume76
Issue number3
DOIs
StatePublished - Jul 1 1987

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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