Linking data to models: Data regression

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Abstract

Mathematical models are an essential tool in systems biology, linking the behaviour of a system to the interactions between its components. Parameters in empirical mathematical models must be determined using experimental data, a process called regression. Because experimental data are noisy and incomplete, diagnostics that test the structural identifiability and validity of models and the significance and determinability of their parameters are needed to ensure that the proposed models are supported by the available data.

Original languageEnglish (US)
Pages (from-to)813-819
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2006

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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