Linking Retroelements to Autoimmunity

Vijay G. Bhoj; Zhijian J. Chen

doi:10.1016/j.cell.2008.08.010

Linking Retroelements to Autoimmunity

Vijay G. Bhoj, Zhijian J. Chen

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

Original language	English (US)
Pages (from-to)	569-571
Number of pages	3
Journal	Cell
Volume	134
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2008.08.010
State	Published - Aug 22 2008

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2008.08.010

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title = "Linking Retroelements to Autoimmunity",

abstract = "In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.",

author = "Bhoj, {Vijay G.} and Chen, {Zhijian J.}",

note = "Funding Information: We thank J. Cabrera for expert assistance in preparation of the figure. Research in the Chen laboratory is supported by grants from the NIH and the Welch Foundation. Z.J.C. is an HHMI investigator.",

year = "2008",

month = aug,

day = "22",

doi = "10.1016/j.cell.2008.08.010",

language = "English (US)",

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journal = "Cell",

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T1 - Linking Retroelements to Autoimmunity

AU - Bhoj, Vijay G.

AU - Chen, Zhijian J.

N1 - Funding Information: We thank J. Cabrera for expert assistance in preparation of the figure. Research in the Chen laboratory is supported by grants from the NIH and the Welch Foundation. Z.J.C. is an HHMI investigator.

PY - 2008/8/22

Y1 - 2008/8/22

N2 - In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

AB - In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

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DO - 10.1016/j.cell.2008.08.010

M3 - Short survey

C2 - 18724930

AN - SCOPUS:49549122469

SN - 0092-8674

VL - 134

SP - 569

EP - 571

JO - Cell

JF - Cell

IS - 4

ER -

Linking Retroelements to Autoimmunity

Abstract

ASJC Scopus subject areas

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