Linking Retroelements to Autoimmunity

Vijay G. Bhoj, Zhijian J. Chen

Research output: Contribution to journalShort survey

17 Scopus citations

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalCell
Volume134
Issue number4
DOIs
StatePublished - Aug 22 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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