Linking Retroelements to Autoimmunity

Vijay G. Bhoj, Zhijian J. Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalCell
Volume134
Issue number4
DOIs
StatePublished - Aug 22 2008

Fingerprint

Interferon Type I
Retroelements
Autoimmunity
Nucleic Acids
DNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Linking Retroelements to Autoimmunity. / Bhoj, Vijay G.; Chen, Zhijian J.

In: Cell, Vol. 134, No. 4, 22.08.2008, p. 569-571.

Research output: Contribution to journalArticle

Bhoj, Vijay G. ; Chen, Zhijian J. / Linking Retroelements to Autoimmunity. In: Cell. 2008 ; Vol. 134, No. 4. pp. 569-571.
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