Lipid bilayer modules as determinants of K+ channel gating

Ruhma Syeda, Jose S. Santos, Mauricio Montal

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Lipid bilayer composition and asymmetry modulate K+ channel function by unknown mechanisms. Results: Lipid headgroups with exposed hydroxyls on the extracellular facing monolayer stabilize the channel open conformation irrespective of charge. Conclusion: Stabilization is mediated through a change of interfacial water structure. Significance: Lipid bilayer asymmetry and its individual monolayers emerge as crucial determinants of K channel gating.

Original languageEnglish (US)
Pages (from-to)4233-4243
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

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Lipid bilayers
Lipid Bilayers
Monolayers
Hydroxyl Radical
Conformations
Stabilization
Lipids
Water
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Lipid bilayer modules as determinants of K+ channel gating. / Syeda, Ruhma; Santos, Jose S.; Montal, Mauricio.

In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 4233-4243.

Research output: Contribution to journalArticle

Syeda, Ruhma ; Santos, Jose S. ; Montal, Mauricio. / Lipid bilayer modules as determinants of K+ channel gating. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 7. pp. 4233-4243.
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