Lipid mediators of insulin resistance.

William L. Holland, Trina A. Knotts, Jose A. Chavez, Li Ping Wang, Kyle L. Hoehn, Scott A. Summers

Research output: Contribution to journalArticle

Abstract

Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and the metabolic syndrome. We review the metabolic fates of lipids in insulin-responsive tissues and discuss the roles of specific lipid metabolites (e.g., ceramides, GM3 ganglioside, and diacylglycerol) as antagonists of insulin signaling and action.

Original languageEnglish (US)
JournalNutrition Reviews
Volume65
Issue number6 Pt 2
StatePublished - Jun 2007

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insulin resistance
Insulin Resistance
Lipids
lipids
Insulin Antagonists
G(M3) Ganglioside
insulin
Ceramides
Diglycerides
gangliosides
ceramides
Nonesterified Fatty Acids
metabolic syndrome
diacylglycerols
Skeletal Muscle
Obesity
Fats
Research Personnel
skeletal muscle
free fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Holland, W. L., Knotts, T. A., Chavez, J. A., Wang, L. P., Hoehn, K. L., & Summers, S. A. (2007). Lipid mediators of insulin resistance. Nutrition Reviews, 65(6 Pt 2).

Lipid mediators of insulin resistance. / Holland, William L.; Knotts, Trina A.; Chavez, Jose A.; Wang, Li Ping; Hoehn, Kyle L.; Summers, Scott A.

In: Nutrition Reviews, Vol. 65, No. 6 Pt 2, 06.2007.

Research output: Contribution to journalArticle

Holland, WL, Knotts, TA, Chavez, JA, Wang, LP, Hoehn, KL & Summers, SA 2007, 'Lipid mediators of insulin resistance.', Nutrition Reviews, vol. 65, no. 6 Pt 2.
Holland WL, Knotts TA, Chavez JA, Wang LP, Hoehn KL, Summers SA. Lipid mediators of insulin resistance. Nutrition Reviews. 2007 Jun;65(6 Pt 2).
Holland, William L. ; Knotts, Trina A. ; Chavez, Jose A. ; Wang, Li Ping ; Hoehn, Kyle L. ; Summers, Scott A. / Lipid mediators of insulin resistance. In: Nutrition Reviews. 2007 ; Vol. 65, No. 6 Pt 2.
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