Lipid regulators of membrane traffic through the Golgi complex

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Enzymes that modify phospholipids play necessary, but poorly understood, rolex in constitutive membrane traffic. Local production of specific phosphoinositides is required for endocytosis and regulated exocytosis, and enzymes that produce and consume phosphoinositides are components of post- Golgi membrane vesicles. Both biochemical and genetic data indicate that regulation of the membrane content of phosphatidic acid, diacylglycerol and phosphoinositides is necessary for protein traffic from the Golgi complex. Evidence for a regulatory role for lipids earlier in the constitutive secretory pathway is more limited and controversial. Although the mechanisms that regulate traffic between the endoplasmic reticulum and Golgi might be qualitatively different from those that control later membrane transport pathways, recent studies suggest that production of specific lipids is important for transport both into and out of the Golgi. As discussed in this article, one potential mechanism for the involvement of lipids is to control the GTPase cycle of a small GTP-binding protein, ARF (ADP-ribosylation factor).

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalTrends in Cell Biology
Volume9
Issue number5
DOIs
StatePublished - May 1 1999

Fingerprint

Golgi Apparatus
Membrane Lipids
Phosphatidylinositols
Membranes
Lipids
ADP-Ribosylation Factors
Phosphatidic Acids
Secretory Pathway
GTP Phosphohydrolases
Diglycerides
Exocytosis
Enzymes
Endocytosis
GTP-Binding Proteins
Endoplasmic Reticulum
Molecular Biology
Phospholipids
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lipid regulators of membrane traffic through the Golgi complex. / Roth, Michael G.

In: Trends in Cell Biology, Vol. 9, No. 5, 01.05.1999, p. 174-179.

Research output: Contribution to journalArticle

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