TY - JOUR
T1 - Lipid signaling to membrane proteins
T2 - From second messengers to membrane domains and adapter-free endocytosis
AU - Hilgemann, Donald W.
AU - Dai, Gucan
AU - Collins, Anthony
AU - Lariccia, Vincenzo
AU - Magi, Simona
AU - Deisl, Christine
AU - Fine, Michael
N1 - Funding Information:
The interest of our group in the regulation of ion transporters and channels extends over three decades, and it has been our privilege to benefit from the peer review system of JGP over this entire time. From our early work on transmembrane Ca movements in the heart (Hilgemann, 1986) via our studies of different forms of Na-coupled transport (Hilgemann et al., 1992; Lu and Hilgemann, 1999; Kang et al., 2003; Fuster et al., 2008), to work on unconventional membrane turnover (Lariccia et al., 2011), and back to research on Na homeostasis in the heart (Lu and Hilgemann, 2017), the JGP peer review system has been a bedrock of critical help. What makes the difference is the selfless commitment by those involved to foster and improve new scientific work, independent of fads and fashion. In this light, we express our sincere gratitude to all involved and dedicate this article to two of JGP's leaders over decades, Olaf S. Andersen and David C. Gadsby. As editors for work from our group, and innumerable other groups, Olaf and David provided consistently substantive and uncompromising criticism, professional mentoring from the big picture down to line-by-line error corrections, and unrelenting encouragement for us to improve. Their legacies inspire us to continue to try in a difficult time for basic science. Their examples should inspire us all to engage similarly. Supported by National Institutes of Health grant HL119843 to D.W. Hilgemann. The authors declare no competing financial interests. Olaf S. Andersen served as editor
Publisher Copyright:
© 2018 Hilgemann et al.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding. We then switch to our own emerging view that much important lipid signaling occurs via the formation of membrane domains that influence the function of channels and transporters within them, promote selected protein-protein interactions, and control the turnover of surface membrane.
AB - Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding. We then switch to our own emerging view that much important lipid signaling occurs via the formation of membrane domains that influence the function of channels and transporters within them, promote selected protein-protein interactions, and control the turnover of surface membrane.
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U2 - 10.1085/jgp.201711875
DO - 10.1085/jgp.201711875
M3 - Article
C2 - 29326133
AN - SCOPUS:85041407530
SN - 0022-1295
VL - 150
SP - 211
EP - 224
JO - Journal of General Physiology
JF - Journal of General Physiology
IS - 2
ER -