Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis

Donald W. Hilgemann, Gucan Dai, Anthony Collins, Vincenzo Lariccia, Simona Magi, Christine Deisl, Michael Fine

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding. We then switch to our own emerging view that much important lipid signaling occurs via the formation of membrane domains that influence the function of channels and transporters within them, promote selected protein-protein interactions, and control the turnover of surface membrane.

Original languageEnglish (US)
Pages (from-to)211-224
Number of pages14
JournalJournal of General Physiology
Volume150
Issue number2
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Physiology

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