Lipids and adipokines as risk factors for Alzheimer's disease

Matthew W. Warren; Linda S. Hynan; Myron F. Weiner; Rachelle Doody; Susan Rountree; Violeta Capriles; Christie Ballantyne; Eveleen Darby; Tracy Dawson; Aline Hittle; Aisha Khaleeg; Sid O'Bryant; Paula Grammas; Benjamin Williams; Chuang Kuo Wu; Yan Zhang; Gregory Schrimsher; Andrew Dentino; Parastoo Momeni; Larry Hill; Thomas Fairchild; Janice Knebl; Robert Barber; Douglas Mains; Lisa Alvarez; Perrie Adams; Roger Rosenberg; Joan Reisch; Ryan Huebinger; Doris Svetlik; Janet Smith Mechelle Murray; Tomequa Sears; Donald Royall; Helen Hazuda; Raymond Palmer; Marsha Polk

doi:10.3233/JAD-2012-111385

Lipids and adipokines as risk factors for Alzheimer's disease

Matthew W. Warren, Linda S. Hynan, Myron F. Weiner, Rachelle Doody, Susan Rountree, Violeta Capriles, Christie Ballantyne, Eveleen Darby, Tracy Dawson, Aline Hittle, Aisha Khaleeg, Sid O'Bryant, Paula Grammas, Benjamin Williams, Chuang Kuo Wu, Yan Zhang, Gregory Schrimsher, Andrew Dentino, Parastoo Momeni, Larry HillThomas Fairchild, Janice Knebl, Robert Barber, Douglas Mains, Lisa Alvarez, Perrie Adams, Roger Rosenberg, Joan Reisch, Ryan Huebinger, Doris Svetlik, Janet Smith Mechelle Murray, Tomequa Sears, Donald Royall, Helen Hazuda, Raymond Palmer, Marsha Polk

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

Original language	English (US)
Pages (from-to)	151-157
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	29
Issue number	1
DOIs	https://doi.org/10.3233/JAD-2012-111385
State	Published - 2012

Keywords

Adiponectin
Alzheimer's disease
cholesterol
leptin

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-2012-111385

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Warren, M. W., Hynan, L. S., Weiner, M. F., Doody, R., Rountree, S., Capriles, V., Ballantyne, C., Darby, E., Dawson, T., Hittle, A., Khaleeg, A., O'Bryant, S., Grammas, P., Williams, B., Wu, C. K., Zhang, Y., Schrimsher, G., Dentino, A., Momeni, P., ... Polk, M. (2012). Lipids and adipokines as risk factors for Alzheimer's disease. Journal of Alzheimer's Disease, 29(1), 151-157. https://doi.org/10.3233/JAD-2012-111385

Warren, MW, Hynan, LS, Weiner, MF, Doody, R, Rountree, S, Capriles, V, Ballantyne, C, Darby, E, Dawson, T, Hittle, A, Khaleeg, A, O'Bryant, S, Grammas, P, Williams, B, Wu, CK, Zhang, Y, Schrimsher, G, Dentino, A, Momeni, P, Hill, L, Fairchild, T, Knebl, J, Barber, R, Mains, D, Alvarez, L, Adams, P , Rosenberg, R , Reisch, J, Huebinger, R, Svetlik, D, Murray, JSM, Sears, T, Royall, D, Hazuda, H, Palmer, R & Polk, M 2012, 'Lipids and adipokines as risk factors for Alzheimer's disease', Journal of Alzheimer's Disease, vol. 29, no. 1, pp. 151-157. https://doi.org/10.3233/JAD-2012-111385

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abstract = "To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.",

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AU - Williams, Benjamin

AU - Wu, Chuang Kuo

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AU - Schrimsher, Gregory

AU - Dentino, Andrew

AU - Momeni, Parastoo

AU - Hill, Larry

AU - Fairchild, Thomas

AU - Knebl, Janice

AU - Barber, Robert

AU - Mains, Douglas

AU - Alvarez, Lisa

AU - Adams, Perrie

AU - Rosenberg, Roger

AU - Reisch, Joan

AU - Huebinger, Ryan

AU - Svetlik, Doris

AU - Murray, Janet Smith Mechelle

AU - Sears, Tomequa

AU - Royall, Donald

AU - Hazuda, Helen

AU - Palmer, Raymond

AU - Polk, Marsha

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AB - To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

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Lipids and adipokines as risk factors for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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