Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Marina A. Freudenberg; Sandrine Tchaptchet; Simone Keck; György Fejer; Michael Huber; Nicole Schütze; Bruce Beutler; Chris Galanos

doi:10.1016/j.imbio.2007.11.008

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Marina A. Freudenberg, Sandrine Tchaptchet, Simone Keck, György Fejer, Michael Huber, Nicole Schütze, Bruce Beutler, Chris Galanos

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.

Original language	English (US)
Pages (from-to)	193-203
Number of pages	11
Journal	Immunobiology
Volume	213
Issue number	3-4
DOIs	https://doi.org/10.1016/j.imbio.2007.11.008
State	Published - May 14 2008

Keywords

Bacterial infections
Interferons
LPS hypersensitivity
Lipopolysaccharide
TLR
TLR ligands
Viral infections

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Hematology

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Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections : Benefits and hazards of LPS hypersensitivity. / Freudenberg, Marina A.; Tchaptchet, Sandrine; Keck, Simone; Fejer, György; Huber, Michael; Schütze, Nicole; Beutler, Bruce; Galanos, Chris.

In: Immunobiology, Vol. 213, No. 3-4, 14.05.2008, p. 193-203.

Research output: Contribution to journal › Review article › peer-review

Freudenberg, Marina A. ; Tchaptchet, Sandrine ; Keck, Simone ; Fejer, György ; Huber, Michael ; Schütze, Nicole ; Beutler, Bruce ; Galanos, Chris. / Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections : Benefits and hazards of LPS hypersensitivity. In: Immunobiology. 2008 ; Vol. 213, No. 3-4. pp. 193-203.

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AU - Schütze, Nicole

AU - Beutler, Bruce

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Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Abstract

Keywords

ASJC Scopus subject areas

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