Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Marina A. Freudenberg, Sandrine Tchaptchet, Simone Keck, György Fejer, Michael Huber, Nicole Schütze, Bruce Beutler, Chris Galanos

Research output: Contribution to journalReview article

99 Scopus citations

Abstract

In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.

Original languageEnglish (US)
Pages (from-to)193-203
Number of pages11
JournalImmunobiology
Volume213
Issue number3-4
DOIs
StatePublished - May 14 2008

Keywords

  • Bacterial infections
  • Interferons
  • LPS hypersensitivity
  • Lipopolysaccharide
  • TLR
  • TLR ligands
  • Viral infections

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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