TY - JOUR
T1 - Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections
T2 - Benefits and hazards of LPS hypersensitivity
AU - Freudenberg, Marina A.
AU - Tchaptchet, Sandrine
AU - Keck, Simone
AU - Fejer, György
AU - Huber, Michael
AU - Schütze, Nicole
AU - Beutler, Bruce
AU - Galanos, Chris
PY - 2008/5/14
Y1 - 2008/5/14
N2 - In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.
AB - In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.
KW - Bacterial infections
KW - Interferons
KW - LPS hypersensitivity
KW - Lipopolysaccharide
KW - TLR
KW - TLR ligands
KW - Viral infections
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U2 - 10.1016/j.imbio.2007.11.008
DO - 10.1016/j.imbio.2007.11.008
M3 - Review article
C2 - 18406367
AN - SCOPUS:41649093814
VL - 213
SP - 193
EP - 203
JO - Zeitschrift für Immunitätsforschung und experimentelle Therapie
JF - Zeitschrift für Immunitätsforschung und experimentelle Therapie
SN - 0171-2985
IS - 3-4
ER -