Lipopolysaccharide-treated raw 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells

J. R. Mahoney, B. A. Beutler, N. Le Trang, W. Vine, Y. Ikeda, M. Kawakami, A. Cerami

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

RAW 264.7 cells upon stimulation with lipopolysaccharide secrete a protein mediator(s) that suppresses lipoprotein lipase activity in differentiated 3T3-L1 cells. The mediator(s), which is absent from unstimulated culture supernatants, is nondialyzable and thermolabile. Preliminary characterization suggests that this mediator(s) may be the same as that previously found in medium from lipopolysaccharide-treated thioglycollate-elicited mouse peritoneal macrophage cultures.

Original languageEnglish (US)
Pages (from-to)1673-1675
Number of pages3
JournalJournal of Immunology
Volume134
Issue number3
StatePublished - May 1 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Mahoney, J. R., Beutler, B. A., Le Trang, N., Vine, W., Ikeda, Y., Kawakami, M., & Cerami, A. (1985). Lipopolysaccharide-treated raw 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells. Journal of Immunology, 134(3), 1673-1675.