Lipoprotein drug delivery vehicles for cancer: Rationale and reason

Jaideep Chaudhary, Joseph Bower, Ian R. Corbin

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Lipoproteins are a family of naturally occurring macromolecular complexes consisting amphiphilic apoproteins, phospholipids, and neutral lipids. The physiological role of mammalian plasma lipoproteins is to transport their apolar cargo (primarily cholesterol and triglyceride) to their respective destinations through a highly organized ligand-receptor recognition system. Current day synthetic nanoparticle delivery systems attempt to accomplish this task; however, many only manage to achieve limited results. In recent years, many research labs have employed the use of lipoprotein or lipoprotein-like carriers to transport imaging agents or drugs to tumors. The purpose of this review is to highlight the pharmacologic, clinical, and molecular evidence for utilizing lipoprotein-based formulations and discuss their scientific rationale. To accomplish this task, evidence of dynamic drug interactions with circulating plasma lipoproteins are presented. This is followed by epidemiologic and molecular data describing the association between cholesterol and cancer.

Original languageEnglish (US)
Article number6327
JournalInternational journal of molecular sciences
Volume20
Issue number24
DOIs
StatePublished - Dec 2019

Keywords

  • Cancer imaging
  • Cancer therapy
  • Cholesterol
  • Lipoprotein
  • Nanoparticle

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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