Lipoprotein receptors in the vascular wall

Joachim Herz, David Y. Hui

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Purpose of review: We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. Recent findings: Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the endothelium, macrophages and smooth muscle cells communicate with their environment. Summary: Traditionally, lipoprotein receptors were thought of merely as transporters of cholesterol and triglycerides to specific target cells, either for the purpose of delivery and redistribution of nutrients, or for the destruction or clearance of modified (oxidized) lipids by macrophages. Only recently have we begun to appreciate that the same receptors engage in a much more sophisticated and multi-facetted interaction with their environment. Inasmuch, they not only act as mere transporters, but as surprisingly versatile and adaptive signal transducers and modulators throughout the vessel wall. These recent findings now begin to reshape our thinking of how such structurally different and evolutionary unrelated lipoprotein receptors orchestrate the response of the vessel wall to mechanical or metabolic damage.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalCurrent opinion in lipidology
Volume15
Issue number2
DOIs
StatePublished - Apr 2004

Keywords

  • Atherosclerosis
  • Endothelium
  • Macrophage
  • Oxidation
  • Plaque
  • Smooth muscle cell

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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