Lipoprotein receptors

New roles for ancient proteins

Thomas E. Willnow, Anders Nykjaer, Joachim Herz

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This perception has now changed dramatically. Megalin, a member of the low density lipoprotein receptor gene family, turns out to mediate the endocytic uptake of retinoids and steroids, thus helping to regulate their biological function. Other members of this receptor family interact with cytosolic signalling proteins, giving this evolutionary ancient family of receptors an entirely unexpected new role as transducers of extracellular signals.

Original languageEnglish (US)
JournalNature Cell Biology
Volume1
Issue number6
StatePublished - Oct 1999

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Lipoprotein Receptors
Low Density Lipoprotein Receptor-Related Protein-2
LDL Receptors
Retinoids
Transducers
Proteins
Steroids
Lipids
Membranes
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lipoprotein receptors : New roles for ancient proteins. / Willnow, Thomas E.; Nykjaer, Anders; Herz, Joachim.

In: Nature Cell Biology, Vol. 1, No. 6, 10.1999.

Research output: Contribution to journalArticle

Willnow, Thomas E. ; Nykjaer, Anders ; Herz, Joachim. / Lipoprotein receptors : New roles for ancient proteins. In: Nature Cell Biology. 1999 ; Vol. 1, No. 6.
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