Lipotoxicity and B cell maintenance in obesity and type 2 diabetes

Risheng Ye, Toshiharu Onodera, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Obesity and diabetes are often associated with lipotoxic conditions in multiple tissues. The insulin-producing b cells are susceptible to elevated lipid levels and the ensuing lipotoxicity. The preservation of b cell mass and function is one of the main goals of diabetes management under these metabolically stressful conditions. However, the adverse effects from the adaptive signaling pathways that b cells use to counteract lipotoxic stress have secondary negative effects in their own right. Antilipotoxic signaling cascades in b cells can contribute to their eventual failure. Such dual roles are seen for many other biological adaptive processes as well.

Original languageEnglish (US)
Pages (from-to)617-631
Number of pages15
JournalJournal of the Endocrine Society
Issue number3
StatePublished - Mar 2019


  • Adaptive signaling
  • B cell
  • Diabetes
  • Insulin-sparing effect
  • Lipotoxicity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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