Abstract
Obesity and diabetes are often associated with lipotoxic conditions in multiple tissues. The insulin-producing b cells are susceptible to elevated lipid levels and the ensuing lipotoxicity. The preservation of b cell mass and function is one of the main goals of diabetes management under these metabolically stressful conditions. However, the adverse effects from the adaptive signaling pathways that b cells use to counteract lipotoxic stress have secondary negative effects in their own right. Antilipotoxic signaling cascades in b cells can contribute to their eventual failure. Such dual roles are seen for many other biological adaptive processes as well.
Original language | English (US) |
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Pages (from-to) | 617-631 |
Number of pages | 15 |
Journal | Journal of the Endocrine Society |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2019 |
Keywords
- Adaptive signaling
- B cell
- Diabetes
- Insulin-sparing effect
- Lipotoxicity
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism