Listeria monocytogenes: Nasty pathogen but useful tool for vaccine development

Maria V. Tkachuk, Felix O. Yarovinsky, Alexander G. Tonevitsky

Research output: Contribution to journalArticlepeer-review


Listeria monocytogenes (LM) has become a major pathogen of human foodborne illnesses eliciting meningitis, peritonitis, and abortions with a mortality rate of about 30%. During the course of the disease, LM infects a variety of tissues and cell types due to its capacity to induce its own phagocytosis even into non-phagocytic cells. For over 35 years LM continues to serve as a model to define general paradigms of immunology In this review we focus on the clinical characteristics of listeriosis, on the risk factors involved in the pathogenesis, and discuss the currently accepted approaches to prophylaxis and treatment. We report on novel strategies in vaccine development based on the LM-dependent delivering machinery for immune recognition and induction of immunological memory against desired antigens.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
JournalVoprosy Meditsinskoj Khimii
Issue number3
StatePublished - Jan 1 2000


  • Listeria monocytogenes
  • Listeriosis
  • Phagocytosis
  • Vaccine

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Clinical Biochemistry


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