@inbook{8bdf67f5096e45e4b38b6698646d1f9f,
title = "Liver cancer risk-predictive molecular biomarkers specific to clinico-epidemiological contexts",
abstract = "Hepatocellular carcinoma (HCC) risk prediction is increasingly important because of the low annual HCC incidence in patients with the rapidly emerging non-alcoholic fatty liver disease or cured HCV infection. To date, numerous clinical HCC risk biomarkers and scores have been reported in literature. However, heterogeneity in clinico-epidemiological context, e.g., liver disease etiology, patient race/ethnicity, regional environmental exposure, and lifestyle-related factors, obscure their real clinical utility and applicability. Proper characterization of these factors will help refine HCC risk prediction according to certain clinical context/scenarios and contribute to improved early HCC detection. Molecular factors underlying the clinical heterogeneity encompass various features in host genetics, hepatic and systemic molecular dysregulations, and cross-organ interactions, which may serve as clinical-context-specific biomarkers and/or therapeutic targets. Toward the goal to enable individual-risk-based HCC screening by incorporating the HCC risk biomarkers/scores, their assessment in patient with well-defined clinical context/scenario is critical to gauge their real value and to maximize benefit of the tailored patient management for substantial improvement of the poor HCC prognosis.",
keywords = "Cancer screening, Cirrhosis, Clinical risk score, Hepatocellular carcinoma, Molecular risk score, Precision medicine, Risk prediction",
author = "Naoto Kubota and Naoto Fujiwara and Yujin Hoshida",
note = "Funding Information: This work was supported by Uehara Memorial Foundation funding to N.F. and US NIH (DK099558, CA233794, CA226052), European Commission (ERC-2014-AdG-671231, ERC-2020-ADG-101021417), and Cancer Prevention and Research Institute of Texas (RR180016) to Y.H. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.acr.2022.01.005",
language = "English (US)",
isbn = "9780323983921",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "1--37",
editor = "Sirica, {Alphonse E.} and Sirica, {Alphonse E.} and Fisher, {Paul B.}",
booktitle = "Hepatobiliary Cancers",
}