Liver cell specific targeting of peptide nucleic acid oligomers

Xiao Zhang, Carla G. Simmons, David R. Corey

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

Original languageEnglish (US)
Pages (from-to)1269-1272
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number10
DOIs
StatePublished - May 21 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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