Liver cell specific targeting of peptide nucleic acid oligomers

Xiao Zhang; Carla G. Simmons; David R. Corey

doi:10.1016/S0960-894X(01)00198-6

Liver cell specific targeting of peptide nucleic acid oligomers

Xiao Zhang, Carla G. Simmons, David R. Corey

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

Original language	English (US)
Pages (from-to)	1269-1272
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(01)00198-6
State	Published - May 21 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00198-6

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abstract = "Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.",

author = "Xiao Zhang and Simmons, {Carla G.} and Corey, {David R.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (CA 74708, GM 60642) and the Robert A. Welch Foundation (I-1244).",

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AU - Zhang, Xiao

AU - Simmons, Carla G.

AU - Corey, David R.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (CA 74708, GM 60642) and the Robert A. Welch Foundation (I-1244).

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Y1 - 2001/5/21

N2 - Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

AB - Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

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Liver cell specific targeting of peptide nucleic acid oligomers

Abstract

ASJC Scopus subject areas

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