Liver cell specific targeting of peptide nucleic acid oligomers

Xiao Zhang, Carla G. Simmons, David R. Corey

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.

Original languageEnglish (US)
Pages (from-to)1269-1272
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number10
DOIs
StatePublished - May 21 2001

Fingerprint

Peptide Nucleic Acids
Lactose
Oligomers
Liver
Telomerase
Hep G2 Cells
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Liver cell specific targeting of peptide nucleic acid oligomers. / Zhang, Xiao; Simmons, Carla G.; Corey, David R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 10, 21.05.2001, p. 1269-1272.

Research output: Contribution to journalArticle

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