Liver cell volume regulation: Size matters

Jeffrey C. Dunkelberg, Andrew P. Feranchak, J. Gregory Fitz

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Following the observations of Haussinger and Lang, 6 evidence for important functional interactions between membrane transport, metabolism, and cell volume in liver has continued to accumulate. While all cells are capable of volume regulation, there is increasing evidence in liver that small changes in the set point of volume above or below starting values initiate a complex signaling cascade that involves changes in cellular kinases, protein activity, and gene expression. Moreover, volume-sensitive ATP release provides a pathway for coordinating volume-sensitive responses along the sinusoidal and bile secretory axis. The concept that hepatocyte volume serves as a signal regulating liver cell and organ function provides a conceptual framework for development of new strategies for pharmacologic modulation of liver metabolism and bile formation through effects on volume-sensitive signaling and ion channels.

Original languageEnglish (US)
Pages (from-to)1349-1352
Number of pages4
Issue number6
StatePublished - 2001

ASJC Scopus subject areas

  • Hepatology


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