TY - JOUR
T1 - Liver cell volume regulation
T2 - Size matters
AU - Dunkelberg, Jeffrey C.
AU - Feranchak, Andrew P.
AU - Fitz, J. Gregory
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Following the observations of Haussinger and Lang, 6 evidence for important functional interactions between membrane transport, metabolism, and cell volume in liver has continued to accumulate. While all cells are capable of volume regulation, there is increasing evidence in liver that small changes in the set point of volume above or below starting values initiate a complex signaling cascade that involves changes in cellular kinases, protein activity, and gene expression. Moreover, volume-sensitive ATP release provides a pathway for coordinating volume-sensitive responses along the sinusoidal and bile secretory axis. The concept that hepatocyte volume serves as a signal regulating liver cell and organ function provides a conceptual framework for development of new strategies for pharmacologic modulation of liver metabolism and bile formation through effects on volume-sensitive signaling and ion channels.
AB - Following the observations of Haussinger and Lang, 6 evidence for important functional interactions between membrane transport, metabolism, and cell volume in liver has continued to accumulate. While all cells are capable of volume regulation, there is increasing evidence in liver that small changes in the set point of volume above or below starting values initiate a complex signaling cascade that involves changes in cellular kinases, protein activity, and gene expression. Moreover, volume-sensitive ATP release provides a pathway for coordinating volume-sensitive responses along the sinusoidal and bile secretory axis. The concept that hepatocyte volume serves as a signal regulating liver cell and organ function provides a conceptual framework for development of new strategies for pharmacologic modulation of liver metabolism and bile formation through effects on volume-sensitive signaling and ion channels.
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U2 - 10.1053/jhep.2001.24750
DO - 10.1053/jhep.2001.24750
M3 - Article
C2 - 11391521
AN - SCOPUS:0034991862
SN - 0270-9139
VL - 33
SP - 1349
EP - 1352
JO - Hepatology
JF - Hepatology
IS - 6
ER -