Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai, Ty D. Troutman, Jason S. Seidman, Zhengyu Ouyang, Nathanael J. Spann, Yohei Abe, Kaori M. Ego, Cassi M. Bruni, Zihou Deng, Johannes C.M. Schlachetzki, Alexi Nott, Hunter Bennett, Jonathan Chang, Bao Chau T. Vu, Martina P. Pasillas, Verena M. Link, Lorane Texari, Sven Heinz, Bonne M. Thompson, Jeffrey G. McDonaldFrederic Geissmann, Christopher K. Glass

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.

Original languageEnglish (US)
Pages (from-to)655-670.e8
JournalImmunity
Volume51
Issue number4
DOIs
StatePublished - Oct 15 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., Nott, A., Bennett, H., Chang, J., Vu, B. C. T., Pasillas, M. P., Link, V. M., Texari, L., Heinz, S., Thompson, B. M., ... Glass, C. K. (2019). Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity, 51(4), 655-670.e8. https://doi.org/10.1016/j.immuni.2019.09.002