Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai; Ty D. Troutman; Jason S. Seidman; Zhengyu Ouyang; Nathanael J. Spann; Yohei Abe; Kaori M. Ego; Cassi M. Bruni; Zihou Deng; Johannes C.M. Schlachetzki; Alexi Nott; Hunter Bennett; Jonathan Chang; Bao Chau T. Vu; Martina P. Pasillas; Verena M. Link; Lorane Texari; Sven Heinz; Bonne M. Thompson; Jeffrey G. McDonald; Frederic Geissmann; Christopher K. Glass

doi:10.1016/j.immuni.2019.09.002

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai, Ty D. Troutman, Jason S. Seidman, Zhengyu Ouyang, Nathanael J. Spann, Yohei Abe, Kaori M. Ego, Cassi M. Bruni, Zihou Deng, Johannes C.M. Schlachetzki, Alexi Nott, Hunter Bennett, Jonathan Chang, Bao Chau T. Vu, Martina P. Pasillas, Verena M. Link, Lorane Texari, Sven Heinz, Bonne M. Thompson, Jeffrey G. McDonaldFrederic Geissmann, Christopher K. Glass

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.

Original language	English (US)
Pages (from-to)	655-670.e8
Journal	Immunity
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.09.002
State	Published - Oct 15 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., Nott, A., Bennett, H., Chang, J., Vu, B. C. T., Pasillas, M. P., Link, V. M., Texari, L., Heinz, S., Thompson, B. M., ... Glass, C. K. (2019). Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity, 51(4), 655-670.e8. https://doi.org/10.1016/j.immuni.2019.09.002

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. / Sakai, Mashito; Troutman, Ty D.; Seidman, Jason S.; Ouyang, Zhengyu; Spann, Nathanael J.; Abe, Yohei; Ego, Kaori M.; Bruni, Cassi M.; Deng, Zihou; Schlachetzki, Johannes C.M.; Nott, Alexi; Bennett, Hunter; Chang, Jonathan; Vu, Bao Chau T.; Pasillas, Martina P.; Link, Verena M.; Texari, Lorane; Heinz, Sven; Thompson, Bonne M.; McDonald, Jeffrey G.; Geissmann, Frederic; Glass, Christopher K.

In: Immunity, Vol. 51, No. 4, 15.10.2019, p. 655-670.e8.

Research output: Contribution to journal › Article

Sakai, M, Troutman, TD, Seidman, JS, Ouyang, Z, Spann, NJ, Abe, Y, Ego, KM, Bruni, CM, Deng, Z, Schlachetzki, JCM, Nott, A, Bennett, H, Chang, J, Vu, BCT, Pasillas, MP, Link, VM, Texari, L, Heinz, S, Thompson, BM, McDonald, JG, Geissmann, F & Glass, CK 2019, 'Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity', Immunity, vol. 51, no. 4, pp. 655-670.e8. https://doi.org/10.1016/j.immuni.2019.09.002

Sakai, Mashito ; Troutman, Ty D. ; Seidman, Jason S. ; Ouyang, Zhengyu ; Spann, Nathanael J. ; Abe, Yohei ; Ego, Kaori M. ; Bruni, Cassi M. ; Deng, Zihou ; Schlachetzki, Johannes C.M. ; Nott, Alexi ; Bennett, Hunter ; Chang, Jonathan ; Vu, Bao Chau T. ; Pasillas, Martina P. ; Link, Verena M. ; Texari, Lorane ; Heinz, Sven ; Thompson, Bonne M. ; McDonald, Jeffrey G. ; Geissmann, Frederic ; Glass, Christopher K. / Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. In: Immunity. 2019 ; Vol. 51, No. 4. pp. 655-670.e8.

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title = "Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity",

abstract = "Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.",

author = "Mashito Sakai and Troutman, {Ty D.} and Seidman, {Jason S.} and Zhengyu Ouyang and Spann, {Nathanael J.} and Yohei Abe and Ego, {Kaori M.} and Bruni, {Cassi M.} and Zihou Deng and Schlachetzki, {Johannes C.M.} and Alexi Nott and Hunter Bennett and Jonathan Chang and Vu, {Bao Chau T.} and Pasillas, {Martina P.} and Link, {Verena M.} and Lorane Texari and Sven Heinz and Thompson, {Bonne M.} and McDonald, {Jeffrey G.} and Frederic Geissmann and Glass, {Christopher K.}",

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AU - Sakai, Mashito

AU - Troutman, Ty D.

AU - Seidman, Jason S.

AU - Ouyang, Zhengyu

AU - Spann, Nathanael J.

AU - Abe, Yohei

AU - Ego, Kaori M.

AU - Bruni, Cassi M.

AU - Deng, Zihou

AU - Schlachetzki, Johannes C.M.

AU - Nott, Alexi

AU - Bennett, Hunter

AU - Chang, Jonathan

AU - Vu, Bao Chau T.

AU - Pasillas, Martina P.

AU - Link, Verena M.

AU - Texari, Lorane

AU - Heinz, Sven

AU - Thompson, Bonne M.

AU - McDonald, Jeffrey G.

AU - Geissmann, Frederic

AU - Glass, Christopher K.

PY - 2019/10/15

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