Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai; Ty D. Troutman; Jason S. Seidman; Zhengyu Ouyang; Nathanael J. Spann; Yohei Abe; Kaori M. Ego; Cassi M. Bruni; Zihou Deng; Johannes C.M. Schlachetzki; Alexi Nott; Hunter Bennett; Jonathan Chang; Bao Chau T. Vu; Martina P. Pasillas; Verena M. Link; Lorane Texari; Sven Heinz; Bonne M. Thompson; Jeffrey G. McDonald; Frederic Geissmann; Christopher K. Glass

doi:10.1016/j.immuni.2019.09.002

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai, Ty D. Troutman, Jason S. Seidman, Zhengyu Ouyang, Nathanael J. Spann, Yohei Abe, Kaori M. Ego, Cassi M. Bruni, Zihou Deng, Johannes C.M. Schlachetzki, Alexi Nott, Hunter Bennett, Jonathan Chang, Bao Chau T. Vu, Martina P. Pasillas, Verena M. Link, Lorane Texari, Sven Heinz, Bonne M. Thompson, Jeffrey G. McDonaldFrederic Geissmann, Christopher K. Glass

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.

Original language	English (US)
Pages (from-to)	655-670.e8
Journal	Immunity
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.09.002
State	Published - Oct 15 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1016/j.immuni.2019.09.002

Cite this

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., Nott, A., Bennett, H., Chang, J., Vu, B. C. T., Pasillas, M. P., Link, V. M., Texari, L., Heinz, S., Thompson, B. M., ... Glass, C. K. (2019). Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity, 51(4), 655-670.e8. https://doi.org/10.1016/j.immuni.2019.09.002

Sakai, M, Troutman, TD, Seidman, JS, Ouyang, Z, Spann, NJ, Abe, Y, Ego, KM, Bruni, CM, Deng, Z, Schlachetzki, JCM, Nott, A, Bennett, H, Chang, J, Vu, BCT, Pasillas, MP, Link, VM, Texari, L, Heinz, S, Thompson, BM, McDonald, JG, Geissmann, F & Glass, CK 2019, 'Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity', Immunity, vol. 51, no. 4, pp. 655-670.e8. https://doi.org/10.1016/j.immuni.2019.09.002

@article{f32d248379604cf59a06eff3f9858758,

title = "Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity",

abstract = "Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.",

author = "Mashito Sakai and Troutman, {Ty D.} and Seidman, {Jason S.} and Zhengyu Ouyang and Spann, {Nathanael J.} and Yohei Abe and Ego, {Kaori M.} and Bruni, {Cassi M.} and Zihou Deng and Schlachetzki, {Johannes C.M.} and Alexi Nott and Hunter Bennett and Jonathan Chang and Vu, {Bao Chau T.} and Pasillas, {Martina P.} and Link, {Verena M.} and Lorane Texari and Sven Heinz and Thompson, {Bonne M.} and McDonald, {Jeffrey G.} and Frederic Geissmann and Glass, {Christopher K.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

day = "15",

doi = "10.1016/j.immuni.2019.09.002",

language = "English (US)",

volume = "51",

pages = "655--670.e8",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

AU - Sakai, Mashito

AU - Troutman, Ty D.

AU - Seidman, Jason S.

AU - Ouyang, Zhengyu

AU - Spann, Nathanael J.

AU - Abe, Yohei

AU - Ego, Kaori M.

AU - Bruni, Cassi M.

AU - Deng, Zihou

AU - Schlachetzki, Johannes C.M.

AU - Nott, Alexi

AU - Bennett, Hunter

AU - Chang, Jonathan

AU - Vu, Bao Chau T.

AU - Pasillas, Martina P.

AU - Link, Verena M.

AU - Texari, Lorane

AU - Heinz, Sven

AU - Thompson, Bonne M.

AU - McDonald, Jeffrey G.

AU - Geissmann, Frederic

AU - Glass, Christopher K.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.

AB - Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.

UR - http://www.scopus.com/inward/record.url?scp=85072970394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072970394&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2019.09.002

DO - 10.1016/j.immuni.2019.09.002

M3 - Article

C2 - 31587991

AN - SCOPUS:85072970394

SN - 1074-7613

VL - 51

SP - 655-670.e8

JO - Immunity

JF - Immunity

IS - 4

ER -

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this