@article{f32d248379604cf59a06eff3f9858758,
title = "Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity",
abstract = "Tissue environment has an instructive role in establishing resident macrophage phenotypes. Sakai et al. provide evidence for a two-step model in which liver-derived signals that include DLL4, TGF-β, and desmosterol induce Kupffer cell (liver-resident macrophage) differentiation by regulating the expression and activities of RBPJ, SMADs, and LXRα.",
author = "Mashito Sakai and Troutman, {Ty D.} and Seidman, {Jason S.} and Zhengyu Ouyang and Spann, {Nathanael J.} and Yohei Abe and Ego, {Kaori M.} and Bruni, {Cassi M.} and Zihou Deng and Schlachetzki, {Johannes C.M.} and Alexi Nott and Hunter Bennett and Jonathan Chang and Vu, {Bao Chau T.} and Pasillas, {Martina P.} and Link, {Verena M.} and Lorane Texari and Sven Heinz and Thompson, {Bonne M.} and McDonald, {Jeffrey G.} and Frederic Geissmann and Glass, {Christopher K.}",
note = "Funding Information: These studies were supported by NIH grants DK091183, HL088093, and GM085764 and a Leducq Foundation, France, Transatlantic Network Grant. M.S. was supported by the Manpei Suzuki Diabetes Foundation of Tokyo, Japan, and the Osamu Hayaishi Memorial Scholarship for Study Abroad, Japan. T.D.T. was supported by P30 DK063491, T32DK007044, and National Research Service Award (NRSA) T32CA009523. J.S.S. was supported by American Heart Association Fellowship 16PRE30980030 and NIH Predoctoral Training Grant 5T32DK007541. J.G.M. is supported in part by NIH HL20948. Y.A. was supported by the Japan Society for the Promotion of Science Overseas Research Fellowship. Conceptualization, M.S. T.D.T. J.S.S. Z.O. N.J.S. F.G. and C.K.G.; Methodology, M.S. T.D.T. J.S.S. N.J.S. Z.D. J.C.M.S. A.N. L.T. S.H. B.M.T. and J.G.M.; Formal Analysis, Z.O. M.S. J.S.S. T.D.T. and C.K.G.; Investigation, M.S. T.D.T. J.S.S. Z.O. N.J.S. Y.A. Z.D. K.M.E. C.M.B. H.B. J.C. B.T.V. M.P.P. V.M.L. and B.M.T.; Writing ? Original Draft, C.K.G. and M.S.; Writing ? Review & Editing, M.S. Z.O. T.D.T. J.S.S. and C.K.G.; Visualization, Z.O. M.S. T.D.T. J.S.S. and C.K.G.; Funding Acquisition, C.K.G.; Resources, B.M.T. J.G.M. and F.G.; Supervision, C.K.G. The authors declare no competing interests. Funding Information: These studies were supported by NIH grants DK091183 , HL088093 , and GM085764 and a Leducq Foundation , France, Transatlantic Network Grant. M.S. was supported by the Manpei Suzuki Diabetes Foundation of Tokyo, Japan, and the Osamu Hayaishi Memorial Scholarship for Study Abroad , Japan. T.D.T. was supported by P30 DK063491 , T32DK007044 , and National Research Service Award (NRSA) T32CA009523 . J.S.S. was supported by American Heart Association Fellowship 16PRE30980030 and NIH Predoctoral Training Grant 5T32DK007541 . J.G.M. is supported in part by NIH HL20948 . Y.A. was supported by the Japan Society for the Promotion of Science Overseas Research Fellowship. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "15",
doi = "10.1016/j.immuni.2019.09.002",
language = "English (US)",
volume = "51",
pages = "655--670.e8",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}