Liver histology of acute brucellosis caused by Brucella melitensis

Edward J. Young, Mohammad Reza Hasanjani Roushan, Shariar Shafae, Robert M. Genta, Shari L. Taylor

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

As a major organ of the mononuclear phagocytic system, the liver is probably involved in all cases of brucellosis. In this prospective study, liver slides prepared from percutaneous liver biopsy samples of 20 patients with clinical and laboratory evidence of acute brucellosis due to Brucella melitensis were examined for the presence or absence of granulomas by pathologists in Iran and the United States. Nineteen men and one woman ranging in age from 14 to 62 years were studied. All patients had clinical signs and symptoms compatible with acute brucellosis, and all had significantly elevated titers of antibodies to Brucella in their serum. Liver function tests were mildly elevated in 11 (55%) cases, and C-reactive protein was positive in 15 (65%) patients. Thirteen (65%) patients had blood cultures positive for B melitensis. Iranian and American pathologists reported granulomas in 3 (15%) and in 4 (20%) cases, respectively. There was agreement between Iranian and American pathologists in 17 (85%) cases. The most prevalent findings were mild portal or lobular lymphocytic inflammation (16 cases). Two cases revealed noncaseating epithelioid granulomas, and 2 had microgranulomas. The results show that all patients had microscopic evidence of liver involvement. The predominant histologic finding was mild portal or lobular inflammation with lymphocytes. Granulomas were present in only 4 cases.

Original languageEnglish (US)
Pages (from-to)2023-2028
Number of pages6
JournalHuman Pathology
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Brucella melitensis
Brucellosis
Histology
Granuloma
Liver
Inflammation
Brucella
Liver Function Tests
Iran
C-Reactive Protein
Signs and Symptoms
Prospective Studies
Lymphocytes
Biopsy
Antibodies
Serum
Pathologists

Keywords

  • Brucella melitensis
  • Granuloma
  • Iran
  • Liver
  • Pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Young, E. J., Hasanjani Roushan, M. R., Shafae, S., Genta, R. M., & Taylor, S. L. (2014). Liver histology of acute brucellosis caused by Brucella melitensis. Human Pathology, 45(10), 2023-2028. https://doi.org/10.1016/j.humpath.2014.07.007

Liver histology of acute brucellosis caused by Brucella melitensis. / Young, Edward J.; Hasanjani Roushan, Mohammad Reza; Shafae, Shariar; Genta, Robert M.; Taylor, Shari L.

In: Human Pathology, Vol. 45, No. 10, 01.10.2014, p. 2023-2028.

Research output: Contribution to journalArticle

Young, EJ, Hasanjani Roushan, MR, Shafae, S, Genta, RM & Taylor, SL 2014, 'Liver histology of acute brucellosis caused by Brucella melitensis', Human Pathology, vol. 45, no. 10, pp. 2023-2028. https://doi.org/10.1016/j.humpath.2014.07.007
Young EJ, Hasanjani Roushan MR, Shafae S, Genta RM, Taylor SL. Liver histology of acute brucellosis caused by Brucella melitensis. Human Pathology. 2014 Oct 1;45(10):2023-2028. https://doi.org/10.1016/j.humpath.2014.07.007
Young, Edward J. ; Hasanjani Roushan, Mohammad Reza ; Shafae, Shariar ; Genta, Robert M. ; Taylor, Shari L. / Liver histology of acute brucellosis caused by Brucella melitensis. In: Human Pathology. 2014 ; Vol. 45, No. 10. pp. 2023-2028.
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