Liver transplantation arrests and reverses muscle wasting

Joseph T. Bergerson, Jun Goo Lee, Alessandro Furlan, Achuthan Sourianarayanane, David T. Fetzer, Amit D. Tevar, Douglas P. Landsittel, Andrea F. Dimartini, Michael A. Dunn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Muscle wasting, sarcopenia, is common in advanced cirrhosis and predicts adverse outcomes while awaiting and following liver transplantation. Frequent post-transplant worsening of sarcopenia has attracted recent interest. It is unknown whether this serious problem is an expected metabolic consequence of transplantation or results from confounding conditions such as recurrent allograft liver disease or avoidable post-transplant complications. To clarify this question, we studied pre- and post-transplant muscle mass in a retrospective cohort of 40 patients transplanted for three diseases - alcoholic cirrhosis, non-alcoholic steatohepatitis cirrhosis, and primary sclerosing cholangitis cirrhosis - in whom allograft disease recurrence was monitored and excluded, and who lacked common post-transplant muscle wasting complications such as sepsis, renal failure, ischemia, and cholestasis. We measured skeletal muscle index (SMI) using computed tomography before and 12-48 months after transplant. SMI as a categorical variable significantly improved, from 18 patients above the normal cutoff pre-transplant to 28 post-transplant (p = 0.008). SMI increases were greatest in patients with the lowest pre-transplant SMI (p < 0.01). As a continuous variable, mean SMI remained stable, with a non-significant trend toward improvement. We conclude that after liver transplantation sarcopenia does not progress but is arrested and frequently improves in the absence of confounding conditions.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalClinical Transplantation
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Liver Transplantation
Transplants
Muscles
Sarcopenia
Skeletal Muscle
Fibrosis
Allografts
Alcoholic Liver Cirrhosis
Sclerosing Cholangitis
Cholestasis
Fatty Liver
Renal Insufficiency
Liver Diseases
Sepsis
Ischemia
Transplantation
Tomography
Recurrence

Keywords

  • Cirrhosis
  • Liver
  • Muscle
  • Sarcopenia
  • Transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Bergerson, J. T., Lee, J. G., Furlan, A., Sourianarayanane, A., Fetzer, D. T., Tevar, A. D., ... Dunn, M. A. (2015). Liver transplantation arrests and reverses muscle wasting. Clinical Transplantation, 29(3), 216-221. https://doi.org/10.1111/ctr.12506

Liver transplantation arrests and reverses muscle wasting. / Bergerson, Joseph T.; Lee, Jun Goo; Furlan, Alessandro; Sourianarayanane, Achuthan; Fetzer, David T.; Tevar, Amit D.; Landsittel, Douglas P.; Dimartini, Andrea F.; Dunn, Michael A.

In: Clinical Transplantation, Vol. 29, No. 3, 01.03.2015, p. 216-221.

Research output: Contribution to journalArticle

Bergerson, JT, Lee, JG, Furlan, A, Sourianarayanane, A, Fetzer, DT, Tevar, AD, Landsittel, DP, Dimartini, AF & Dunn, MA 2015, 'Liver transplantation arrests and reverses muscle wasting', Clinical Transplantation, vol. 29, no. 3, pp. 216-221. https://doi.org/10.1111/ctr.12506
Bergerson JT, Lee JG, Furlan A, Sourianarayanane A, Fetzer DT, Tevar AD et al. Liver transplantation arrests and reverses muscle wasting. Clinical Transplantation. 2015 Mar 1;29(3):216-221. https://doi.org/10.1111/ctr.12506
Bergerson, Joseph T. ; Lee, Jun Goo ; Furlan, Alessandro ; Sourianarayanane, Achuthan ; Fetzer, David T. ; Tevar, Amit D. ; Landsittel, Douglas P. ; Dimartini, Andrea F. ; Dunn, Michael A. / Liver transplantation arrests and reverses muscle wasting. In: Clinical Transplantation. 2015 ; Vol. 29, No. 3. pp. 216-221.
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