Living without insulin: The role of leptin signaling in the hypothalamus

Teppei Fujikawa, Roberto Coppari

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Since its discovery in 1922, insulin has been thought to be required for normal metabolic homeostasis and survival. However, this view would need to be revised as recent results from different laboratories have convincingly indicated that life without insulin is possible in rodent models. These data indicate that particular neuronal circuitries, which include hypothalamic leptin-responsive neurons, are empowered with the capability of permitting life in complete absence of insulin. Here, we review the neuronal and peripheral mechanisms by which leptin signaling in the central nervous system (CNS) regulates glucose metabolism in an insulin-independent manner.

Original languageEnglish (US)
Article number108
JournalFrontiers in Neuroscience
Issue numberMAR
StatePublished - 2015


  • Central nervous system
  • Diabetes mellitus
  • Diabetes mellitus type 1
  • Diabetes mellitus type 2
  • Insulin
  • Leptin
  • Leptin receptors

ASJC Scopus subject areas

  • Neuroscience(all)


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