Living without insulin: The role of leptin signaling in the hypothalamus

Teppei Fujikawa, Roberto Coppari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Since its discovery in 1922, insulin has been thought to be required for normal metabolic homeostasis and survival. However, this view would need to be revised as recent results from different laboratories have convincingly indicated that life without insulin is possible in rodent models. These data indicate that particular neuronal circuitries, which include hypothalamic leptin-responsive neurons, are empowered with the capability of permitting life in complete absence of insulin. Here, we review the neuronal and peripheral mechanisms by which leptin signaling in the central nervous system (CNS) regulates glucose metabolism in an insulin-independent manner.

Original languageEnglish (US)
Article number108
JournalFrontiers in Neuroscience
Volume9
Issue numberMAR
DOIs
StatePublished - 2015

Fingerprint

Leptin
Hypothalamus
Insulin
Rodentia
Homeostasis
Central Nervous System
Neurons
Glucose

Keywords

  • Central nervous system
  • Diabetes mellitus
  • Diabetes mellitus type 1
  • Diabetes mellitus type 2
  • Insulin
  • Leptin
  • Leptin receptors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Living without insulin : The role of leptin signaling in the hypothalamus. / Fujikawa, Teppei; Coppari, Roberto.

In: Frontiers in Neuroscience, Vol. 9, No. MAR, 108, 2015.

Research output: Contribution to journalArticle

Fujikawa, Teppei ; Coppari, Roberto. / Living without insulin : The role of leptin signaling in the hypothalamus. In: Frontiers in Neuroscience. 2015 ; Vol. 9, No. MAR.
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