LKB1 as a tumor suppressor in uterine cancer: Mouse models and translational studies

Christopher G. Peña, Diego H. Castrillón

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The LKB1 tumor suppressor was identifi ed in 1998 as the gene mutated in the Peutz–Jeghers Syndrome (PJS), a hereditary cancer predisposition characterized by gastrointestinal polyposis and a high incidence of cancers, particularly carcinomas, at a variety of anatomic sites including the gastrointestinal tract, lung, and female reproductive tract. Women with PJS have a high incidence of carcinomas of the uterine corpus (endometrium) and cervix. The LKB1 gene is also somatically mutated in human cancers arising at these sites. Work in mouse models has highlighted the potency of LKB1 as an endometrial tumor suppressor and its distinctive roles in driving invasive and metastatic growth. These in vivo models represent tractable experimental systems for the discovery of underlying biological principles and molecular processes regulated by LKB1 in the context of tumorigenesis and also serve as useful preclinical model systems for experimental therapeutics. Here we review LKB1’s known roles in mTOR signaling, metabolism, and cell polarity, with an emphasis on human pathology and mouse models relevant to uterine carcinogenesis, including cancers of the uterine corpus and cervix.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages211-241
Number of pages31
Volume943
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume943
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • AMPK
  • Endometrial cancer
  • Genetically engineered mouse models
  • LKB1
  • MTOR
  • STK11
  • Therapeutics
  • Uterine cancer

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Peña, C. G., & Castrillón, D. H. (2017). LKB1 as a tumor suppressor in uterine cancer: Mouse models and translational studies. In Advances in Experimental Medicine and Biology (Vol. 943, pp. 211-241). (Advances in Experimental Medicine and Biology; Vol. 943). Springer New York LLC. https://doi.org/10.1007/978-3-319-43139-0_7