Lobular neoplasia

Helena Hwang, Megan E. Sullivan, Barbara Susnik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although pathologists have recognized the classic forms of lobular neoplasia for decades, our understanding of this disease has changed markedly since its first description. The term lobular neoplasia encompasses a spectrum of entities ranging from atypical lobular hyperplasia to more recently recognized lobular carcinoma in situ (LCIS) variants including LCIS with necrosis and pleomorphic LCIS. Along with an expanded definition of lobular neoplasia, our concept of the pathobiologic potential of these lesions has evolved. While lobular neoplasia has been viewed primarily as a risk marker of invasive breast carcinoma since the late 1970s, there is increasing evidence that they are also non-obligate precursors. In this review, we will address the history of the disease, updated concepts and histologic definitions, and advances in immunohistochemistry and molecular pathology that have shaped both the way we diagnose and manage lobular neoplasia.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalDiagnostic Histopathology
Volume16
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Neoplasms
Molecular Pathology
Hyperplasia
Necrosis
History
Immunohistochemistry
Breast Neoplasms
Breast Carcinoma In Situ
Pathologists

Keywords

  • atypical lobular hyperplasia
  • e-cadherin
  • lobular carcinoma in situ
  • lobular carcinoma in situ variants
  • lobular neoplasia
  • pleomorphic lobular carcinoma in situ

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Lobular neoplasia. / Hwang, Helena; Sullivan, Megan E.; Susnik, Barbara.

In: Diagnostic Histopathology, Vol. 16, No. 7, 07.2010, p. 337-344.

Research output: Contribution to journalArticle

Hwang, H, Sullivan, ME & Susnik, B 2010, 'Lobular neoplasia', Diagnostic Histopathology, vol. 16, no. 7, pp. 337-344. https://doi.org/10.1016/j.mpdhp.2010.03.016
Hwang, Helena ; Sullivan, Megan E. ; Susnik, Barbara. / Lobular neoplasia. In: Diagnostic Histopathology. 2010 ; Vol. 16, No. 7. pp. 337-344.
@article{1e15352629c440999e6e2417e85f83ce,
title = "Lobular neoplasia",
abstract = "Although pathologists have recognized the classic forms of lobular neoplasia for decades, our understanding of this disease has changed markedly since its first description. The term lobular neoplasia encompasses a spectrum of entities ranging from atypical lobular hyperplasia to more recently recognized lobular carcinoma in situ (LCIS) variants including LCIS with necrosis and pleomorphic LCIS. Along with an expanded definition of lobular neoplasia, our concept of the pathobiologic potential of these lesions has evolved. While lobular neoplasia has been viewed primarily as a risk marker of invasive breast carcinoma since the late 1970s, there is increasing evidence that they are also non-obligate precursors. In this review, we will address the history of the disease, updated concepts and histologic definitions, and advances in immunohistochemistry and molecular pathology that have shaped both the way we diagnose and manage lobular neoplasia.",
keywords = "atypical lobular hyperplasia, e-cadherin, lobular carcinoma in situ, lobular carcinoma in situ variants, lobular neoplasia, pleomorphic lobular carcinoma in situ",
author = "Helena Hwang and Sullivan, {Megan E.} and Barbara Susnik",
year = "2010",
month = "7",
doi = "10.1016/j.mpdhp.2010.03.016",
language = "English (US)",
volume = "16",
pages = "337--344",
journal = "Diagnostic Histopathology",
issn = "1756-2317",
publisher = "Elsevier BV",
number = "7",

}

TY - JOUR

T1 - Lobular neoplasia

AU - Hwang, Helena

AU - Sullivan, Megan E.

AU - Susnik, Barbara

PY - 2010/7

Y1 - 2010/7

N2 - Although pathologists have recognized the classic forms of lobular neoplasia for decades, our understanding of this disease has changed markedly since its first description. The term lobular neoplasia encompasses a spectrum of entities ranging from atypical lobular hyperplasia to more recently recognized lobular carcinoma in situ (LCIS) variants including LCIS with necrosis and pleomorphic LCIS. Along with an expanded definition of lobular neoplasia, our concept of the pathobiologic potential of these lesions has evolved. While lobular neoplasia has been viewed primarily as a risk marker of invasive breast carcinoma since the late 1970s, there is increasing evidence that they are also non-obligate precursors. In this review, we will address the history of the disease, updated concepts and histologic definitions, and advances in immunohistochemistry and molecular pathology that have shaped both the way we diagnose and manage lobular neoplasia.

AB - Although pathologists have recognized the classic forms of lobular neoplasia for decades, our understanding of this disease has changed markedly since its first description. The term lobular neoplasia encompasses a spectrum of entities ranging from atypical lobular hyperplasia to more recently recognized lobular carcinoma in situ (LCIS) variants including LCIS with necrosis and pleomorphic LCIS. Along with an expanded definition of lobular neoplasia, our concept of the pathobiologic potential of these lesions has evolved. While lobular neoplasia has been viewed primarily as a risk marker of invasive breast carcinoma since the late 1970s, there is increasing evidence that they are also non-obligate precursors. In this review, we will address the history of the disease, updated concepts and histologic definitions, and advances in immunohistochemistry and molecular pathology that have shaped both the way we diagnose and manage lobular neoplasia.

KW - atypical lobular hyperplasia

KW - e-cadherin

KW - lobular carcinoma in situ

KW - lobular carcinoma in situ variants

KW - lobular neoplasia

KW - pleomorphic lobular carcinoma in situ

UR - http://www.scopus.com/inward/record.url?scp=77953231317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953231317&partnerID=8YFLogxK

U2 - 10.1016/j.mpdhp.2010.03.016

DO - 10.1016/j.mpdhp.2010.03.016

M3 - Article

VL - 16

SP - 337

EP - 344

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

SN - 1756-2317

IS - 7

ER -