Local gyrification index in Probands with psychotic disorders and their first-degree relatives

Pranav Nanda, Neeraj Tandon, Ian T. Mathew, Christoforos I. Giakoumatos, Hulegar A. Abhishekh, Brett A. Clementz, Godfrey D. Pearlson, John Sweeney, Carol A. Tamminga, Matcheri S. Keshavan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype. Methods Regional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for schizophrenia, SZA, and bipolar disorder. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values. Results Probands exhibited significant hypogyria compared with control subjects in three brain regions and relatives with Axis II cluster A disorders showed nearly significant hypogyria in these same regions. Local gyrification index values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant hypogyria were most widespread in SZA. Conclusions Psychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalBiological Psychiatry
Volume76
Issue number6
DOIs
StatePublished - Sep 15 2014

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Psychotic Disorders
Endophenotypes
Bipolar Disorder
Schizophrenia
Gyrus Cinguli
Sample Size
Software
Brain

Keywords

  • Bipolar
  • cortical folding
  • gyrification
  • psychosis
  • schizoaffective
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Nanda, P., Tandon, N., Mathew, I. T., Giakoumatos, C. I., Abhishekh, H. A., Clementz, B. A., ... Keshavan, M. S. (2014). Local gyrification index in Probands with psychotic disorders and their first-degree relatives. Biological Psychiatry, 76(6), 447-455. https://doi.org/10.1016/j.biopsych.2013.11.018

Local gyrification index in Probands with psychotic disorders and their first-degree relatives. / Nanda, Pranav; Tandon, Neeraj; Mathew, Ian T.; Giakoumatos, Christoforos I.; Abhishekh, Hulegar A.; Clementz, Brett A.; Pearlson, Godfrey D.; Sweeney, John; Tamminga, Carol A.; Keshavan, Matcheri S.

In: Biological Psychiatry, Vol. 76, No. 6, 15.09.2014, p. 447-455.

Research output: Contribution to journalArticle

Nanda, P, Tandon, N, Mathew, IT, Giakoumatos, CI, Abhishekh, HA, Clementz, BA, Pearlson, GD, Sweeney, J, Tamminga, CA & Keshavan, MS 2014, 'Local gyrification index in Probands with psychotic disorders and their first-degree relatives', Biological Psychiatry, vol. 76, no. 6, pp. 447-455. https://doi.org/10.1016/j.biopsych.2013.11.018
Nanda P, Tandon N, Mathew IT, Giakoumatos CI, Abhishekh HA, Clementz BA et al. Local gyrification index in Probands with psychotic disorders and their first-degree relatives. Biological Psychiatry. 2014 Sep 15;76(6):447-455. https://doi.org/10.1016/j.biopsych.2013.11.018
Nanda, Pranav ; Tandon, Neeraj ; Mathew, Ian T. ; Giakoumatos, Christoforos I. ; Abhishekh, Hulegar A. ; Clementz, Brett A. ; Pearlson, Godfrey D. ; Sweeney, John ; Tamminga, Carol A. ; Keshavan, Matcheri S. / Local gyrification index in Probands with psychotic disorders and their first-degree relatives. In: Biological Psychiatry. 2014 ; Vol. 76, No. 6. pp. 447-455.
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abstract = "Background Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype. Methods Regional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for schizophrenia, SZA, and bipolar disorder. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values. Results Probands exhibited significant hypogyria compared with control subjects in three brain regions and relatives with Axis II cluster A disorders showed nearly significant hypogyria in these same regions. Local gyrification index values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant hypogyria were most widespread in SZA. Conclusions Psychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.",
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AU - Tandon, Neeraj

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AU - Abhishekh, Hulegar A.

AU - Clementz, Brett A.

AU - Pearlson, Godfrey D.

AU - Sweeney, John

AU - Tamminga, Carol A.

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N2 - Background Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype. Methods Regional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for schizophrenia, SZA, and bipolar disorder. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values. Results Probands exhibited significant hypogyria compared with control subjects in three brain regions and relatives with Axis II cluster A disorders showed nearly significant hypogyria in these same regions. Local gyrification index values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant hypogyria were most widespread in SZA. Conclusions Psychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.

AB - Background Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype. Methods Regional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values were examined grouped across psychotic diagnoses and then separately for schizophrenia, SZA, and bipolar disorder. Familiality (heritability) values and correlations with clinical measures were also calculated for regional LGI values. Results Probands exhibited significant hypogyria compared with control subjects in three brain regions and relatives with Axis II cluster A disorders showed nearly significant hypogyria in these same regions. Local gyrification index values in these locations were significantly heritable and uncorrelated with any clinical measure. Observations of significant hypogyria were most widespread in SZA. Conclusions Psychotic disorders appear to be characterized by significant regionally localized hypogyria, particularly in cingulate cortex. This abnormality may be a structural endophenotype marking risk for psychotic illness and it may help elucidate etiological underpinnings of psychotic disorders.

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