Localization and therapy of urinary tract infections of childhood

R. L. Wientzen, G. H. McCracken, M. L. Petruska, S. G. Swinson, B. Kaijser, L. A. Hanson

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

One hundred four patients with 124 episodes of urinary tract infection were studied. Serum C-reactive protein (CRP) was determined on diagnosis of each patient. Children with a CRP equal to or greater than 30 μg/ml (CRP-pos) differed significantly from those with values less than 30 μg/ml (CRP-neg) in age, clinical presentation, K type of Escherichia coli causing disease, frequency or radiographic abnormalities, and presence of antibody coating of bacteria in the urinary sediment. E. coli K1 strains caused disease significantly more often in CRP-pos than in CRP-neg patients, and children with K1 infections were younger than those with non-K1 infections. The antibody-coated bacteria test was neither sensitive nor specific for localization of infection in pediatric patients. Determination of K1 antibody concentrations in serum and urine of E. coli K1-infected children provided data supporting the measurement of CRP as one means of localizing urinary tract infections. Patients with CRP-neg infections were treated as successfully with four days of antimicrobial therapy as with ten days.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalPediatrics
Volume63
Issue number3
StatePublished - 1979

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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