Localized eye area sensitivity syndrome (LEASS) describes a collection of subjective and objective symptoms that occur when susceptible individuals apply moisturizers, eye creams, and wrinkle creams containing certain chemicals to the periocular area. Women experiencing this syndrome complain of symptoms ranging from itchy, burning, stinging, and watery eyes to foreign body sensations. Ophthalmologic and dermatologic examinations reveal erythematous skin reactions and bulbar conjunctival chemosis and injection. Ocular surface changes are not observed in patients with LEASS. Onset of symptoms occurs within minutes following the application of the cosmetic and may last up to 48 hr. During the latter stages of LEASS, the patient may complain of a dull, aching feeling in the periocular area.
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