Location Matters: Profiling Diffuse Type Gastric Cancer at the Single-Cell Level

Huocong Huang; Rolf A. Brekken

doi:10.1158/1078-0432.CCR-21-2935

Location Matters: Profiling Diffuse Type Gastric Cancer at the Single-Cell Level

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Abstract

Spatial single-cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells. _2021 American Association for Cancer Research.

Original language	English (US)
Pages (from-to)	6284-6286
Number of pages	3
Journal	Clinical Cancer Research
Volume	27
Issue number	23
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-2935
State	Published - Dec 1 2021

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-21-2935

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title = "Location Matters: Profiling Diffuse Type Gastric Cancer at the Single-Cell Level",

abstract = "Spatial single-cell transcriptomics of primary patient diffuse type gastric cancer reveals distinct cancer and stromal cell differences based on location. Expression of CCL2 by stromal cells in deep tumor regions is highlighted as potentially driving the immunosuppressive microenvironment and enhancing (directly or indirectly) the invasive capacity of tumor cells. _2021 American Association for Cancer Research.",

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Location Matters: Profiling Diffuse Type Gastric Cancer at the Single-Cell Level

Abstract

ASJC Scopus subject areas

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