Location of chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse

C. M. Wilson, E. G. Erdos, J. D. Wilson, B. A. Taylor

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-I, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity resembled that of one or other progenitor strains, as excepted if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.

Original languageEnglish (US)
Pages (from-to)5623-5626
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number11
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Location of chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse'. Together they form a unique fingerprint.

  • Cite this