Abstract
Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-I, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity resembled that of one or other progenitor strains, as excepted if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5623-5626 |
| Number of pages | 4 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 75 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1978 |
ASJC Scopus subject areas
- General