Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA

Dwaine A. Braasch, David R. Corey

Research output: Contribution to journalShort survey

429 Scopus citations

Abstract

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalChemistry and Biology
Volume8
Issue number1
DOIs
StatePublished - Mar 3 2001

Keywords

  • DNA recognition
  • Gene expression control
  • Locked nucleic acid
  • RNA recognition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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