Locus coeruleus and dopaminergic consolidation of everyday memory

Tomonori Takeuchi, Adrian J. Duszkiewicz, Alex Sonneborn, Patrick A. Spooner, Miwako Yamasaki, Masahiko Watanabe, Caroline C. Smith, Guillén Fernández, Karl Deisseroth, Robert W. Greene, Richard G M Morris

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH+) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH+ neurons project more profusely than ventral tegmental area TH+ neurons to the hippocampus, optogenetic activation of locus coeruleus TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalNature
Volume537
Issue number7620
DOIs
StatePublished - 2016

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Locus Coeruleus
Ventral Tegmental Area
Neurons
Hippocampus
Optogenetics
Episodic Memory
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Synaptic Transmission
Adrenergic Receptors
Dopamine
Memory Consolidation

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., ... Morris, R. G. M. (2016). Locus coeruleus and dopaminergic consolidation of everyday memory. Nature, 537(7620), 357-362. https://doi.org/10.1038/nature19325

Locus coeruleus and dopaminergic consolidation of everyday memory. / Takeuchi, Tomonori; Duszkiewicz, Adrian J.; Sonneborn, Alex; Spooner, Patrick A.; Yamasaki, Miwako; Watanabe, Masahiko; Smith, Caroline C.; Fernández, Guillén; Deisseroth, Karl; Greene, Robert W.; Morris, Richard G M.

In: Nature, Vol. 537, No. 7620, 2016, p. 357-362.

Research output: Contribution to journalArticle

Takeuchi, T, Duszkiewicz, AJ, Sonneborn, A, Spooner, PA, Yamasaki, M, Watanabe, M, Smith, CC, Fernández, G, Deisseroth, K, Greene, RW & Morris, RGM 2016, 'Locus coeruleus and dopaminergic consolidation of everyday memory', Nature, vol. 537, no. 7620, pp. 357-362. https://doi.org/10.1038/nature19325
Takeuchi T, Duszkiewicz AJ, Sonneborn A, Spooner PA, Yamasaki M, Watanabe M et al. Locus coeruleus and dopaminergic consolidation of everyday memory. Nature. 2016;537(7620):357-362. https://doi.org/10.1038/nature19325
Takeuchi, Tomonori ; Duszkiewicz, Adrian J. ; Sonneborn, Alex ; Spooner, Patrick A. ; Yamasaki, Miwako ; Watanabe, Masahiko ; Smith, Caroline C. ; Fernández, Guillén ; Deisseroth, Karl ; Greene, Robert W. ; Morris, Richard G M. / Locus coeruleus and dopaminergic consolidation of everyday memory. In: Nature. 2016 ; Vol. 537, No. 7620. pp. 357-362.
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