Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete

Katherine N. Maloney, John B. MacMillan, Christopher A. Kauffman, Paul R. Jensen, Antonio G. Dipasquale, Arnold L. Rheingold, William Fenical

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51 Scopus citations

Abstract

"Chemical Equation Presented" Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC 50 = 3.6 μM.

Original languageEnglish (US)
Pages (from-to)5422-5424
Number of pages3
JournalOrganic Letters
Volume11
Issue number23
DOIs
StatePublished - Dec 3 2009

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ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Maloney, K. N., MacMillan, J. B., Kauffman, C. A., Jensen, P. R., Dipasquale, A. G., Rheingold, A. L., & Fenical, W. (2009). Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete. Organic Letters, 11(23), 5422-5424. https://doi.org/10.1021/ol901997k