Lofexidine in the treatment of hypertension: A twice-daily versus once-daily dose comparison with 24-hour blood pressure monitoring

B. N. Garrett, Norman M Kaplan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lofexidine, an antihypertensive imidazoline derivative, was given to ten hypertensives on both a twice-daily and once-daily regimen, using routine blood pressure measurements and 24-hour Remler recording. Plasma renin activity and catecholamines were measured. After a dose titration with twice-daily doses, the total twice-daily dose was given once daily for two weeks and the drug abruptly withdrawn. Mean placebo blood pressure was 136/104 mm Hg supine. After twice-daily therapy, this fell to 118/86 mm Hg, and upon conversion to once-daily therapy, it rose to 126/89 mm Hg. With the Remler recorder, mean 24-hour blood pressure was 125/89 during the twice-daily therapy, 133/94 mm Hg during once-daily therapy, and 142/99 mm Hg on the day after acute withdrawal; i.e., evaluation in all three treatment periods showed a lack of sustained control with both a wide range and high frequency of blood pressure variation. Plasma renin activity and plasma epinephrine and norepinephrine did not change significantly during the study.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalJournal of Clinical Pharmacology
Volume21
Issue number4
StatePublished - 1981

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Blood Pressure
Hypertension
Renin
Imidazolines
Therapeutics
Antihypertensive Agents
Epinephrine
Catecholamines
Norepinephrine
Placebos
lofexidine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lofexidine in the treatment of hypertension : A twice-daily versus once-daily dose comparison with 24-hour blood pressure monitoring. / Garrett, B. N.; Kaplan, Norman M.

In: Journal of Clinical Pharmacology, Vol. 21, No. 4, 1981, p. 173-180.

Research output: Contribution to journalArticle

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