Lofexidine in the Treatment of Hypertension: A Twice‐Daily versus Once‐Daily Dose Comparison with 24‐Hour Blood Pressure Monitoring

B. N. Garrett, Norman M Kaplan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Abstract: Lofexidine, an antihypertensive imidazoline derivative, was given to ten hypertensives on both a twice‐daily and once‐daily regimen, using routine blood pressure measurements and 24‐hour Remler recording. Plasma renin activity and catecholamines were measured. After a dose titration with twice‐daily doses, the total twice‐daily dose was given once daily for two weeks and the drug abruptly withdrawn. Mean placebo blood pressure was 136/104 mm Hg supine. After twice‐daily therapy, this fell to 118/86 mm Hg, and upon conversion to once‐daily therapy, it rose to 126/89 mm Hg. With the Remler recorder, mean 24‐hour blood pressure was 125/89 during the twice‐daily therapy, 133/94 mm Hg during once‐daily therapy, and 142/99 mm Hg on the day after acute withdrawal; i.e., evaluation in all three treatment periods showed a lack of sustained control with both a wide range and high frequency of blood pressure variation. Plasma renin activity and plasma epinephrine and norepinephrine did not change significantly during the study. 1981 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalThe Journal of Clinical Pharmacology
Volume21
Issue number4
DOIs
StatePublished - Apr 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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