Long-lasting and efficient tumor imaging using a high relaxivity polysaccharide nanogel magnetic resonance imaging contrast agent

Minnie Chan, Jacques Lux, Tomoki Nishimura, Kazunari Akiyoshi, Adah Almutairi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Clinically approved small-molecule magnetic resonance imaging (MRI) contrast agents are all rapidly cleared from the body and offer weak signal enhancement. To avoid repeated administration of contrast agent and improve signal-to-noise ratios, agents with stronger signal enhancement and better retention in tumors are needed. Therefore, we focused on hydrogels because of their excellent water accessibility and biodegradability. Gadolinium (Gd)-chelating cross-linkers were incorporated into self-assembled pullulan nanogels to both impart magnetic properties and to stabilize this material that has been extensively studied for medical applications. We show that these Gd-chelating pullulan nanogels (Gd-CHPOA) have the highest reported relaxivity for any hydrogel-based particles and accumulate in the 4T1 tumors in mice at high levels 4 h after injection. This combination offers high signal enhancement and lasts up to 7 days to delineate the tumor clearly for longer imaging time scales. Importantly, this long-term accumulation does not cause any damage or toxicity in major organs up to three months after injection. Our work highlights the clinical potential of Gd-CHPOA as a tumor-imaging MRI contrast agent, permitting tumor identification and assessment with a high signal-to-background ratio.

Original languageEnglish (US)
Pages (from-to)2964-2971
Number of pages8
JournalBiomacromolecules
Volume16
Issue number9
DOIs
StatePublished - Sep 14 2015

Fingerprint

Magnetic resonance
Polysaccharides
Contrast Media
Gadolinium
Tumors
Imaging techniques
Chelation
Hydrogels
Hydrogel
Biodegradability
Medical applications
Particles (particulate matter)
Toxicity
Magnetic properties
Signal to noise ratio
NanoGel
Molecules
Water
pullulan

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Long-lasting and efficient tumor imaging using a high relaxivity polysaccharide nanogel magnetic resonance imaging contrast agent. / Chan, Minnie; Lux, Jacques; Nishimura, Tomoki; Akiyoshi, Kazunari; Almutairi, Adah.

In: Biomacromolecules, Vol. 16, No. 9, 14.09.2015, p. 2964-2971.

Research output: Contribution to journalArticle

Chan, Minnie ; Lux, Jacques ; Nishimura, Tomoki ; Akiyoshi, Kazunari ; Almutairi, Adah. / Long-lasting and efficient tumor imaging using a high relaxivity polysaccharide nanogel magnetic resonance imaging contrast agent. In: Biomacromolecules. 2015 ; Vol. 16, No. 9. pp. 2964-2971.
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