TY - JOUR
T1 - Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)
AU - Benito-León, Julián
AU - Louis, Elan D.
AU - Villarejo-Galende, Alberto
AU - Romero, Juan P.
AU - Bermejo-Pareja, Félix
N1 - Publisher Copyright:
© 2014 American Academy of Neurology.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective: To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality. Methods: In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: ≤5 hours (short sleepers), 6-8 hours (reference category), and ≥9 hours (long sleepers). Communitydwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined. Results: A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers = 1.58, p = 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p = 0.03). Conclusions: Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.
AB - Objective: To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality. Methods: In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: ≤5 hours (short sleepers), 6-8 hours (reference category), and ≥9 hours (long sleepers). Communitydwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined. Results: A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers = 1.58, p = 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p = 0.03). Conclusions: Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.
UR - http://www.scopus.com/inward/record.url?scp=84925549996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925549996&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000000915
DO - 10.1212/WNL.0000000000000915
M3 - Article
C2 - 25253755
AN - SCOPUS:84925549996
SN - 0028-3878
VL - 83
SP - 1530
EP - 1537
JO - Neurology
JF - Neurology
IS - 17
ER -