Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure

Rochelle L. Goldsmith, J. Thomas Bigger, Daniel M. Bloomfield, Henry Krum, Richard C. Steinman, Jonathan Sackner-Bernstein, Milton Packer

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

To determine the effect of β blockade on parasympathetic nervous system activity, we assessed RR variability during 24-hour Holter monitoring in 10 patients with congestive heart failure before and after 3 to 4 months of treatment with the β blocker carvedilol. High-frequency power increased from 26 to 64 ms2, root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms2, and percentage of absolute differences >50 ms between successive normal RR intervals increased from 0.8% to 4.7%, all p < 0.01, indicating a substantial increase in parasympathetic modulation of RR intervals.

Original languageEnglish (US)
Pages (from-to)1101-1104
Number of pages4
JournalAmerican Journal of Cardiology
Volume80
Issue number8
DOIs
StatePublished - Oct 15 1997

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Parasympathetic Nervous System
Ambulatory Electrocardiography
Heart Failure
Therapeutics
carvedilol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Goldsmith, R. L., Bigger, J. T., Bloomfield, D. M., Krum, H., Steinman, R. C., Sackner-Bernstein, J., & Packer, M. (1997). Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure. American Journal of Cardiology, 80(8), 1101-1104. https://doi.org/10.1016/S0002-9149(97)00616-4

Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure. / Goldsmith, Rochelle L.; Bigger, J. Thomas; Bloomfield, Daniel M.; Krum, Henry; Steinman, Richard C.; Sackner-Bernstein, Jonathan; Packer, Milton.

In: American Journal of Cardiology, Vol. 80, No. 8, 15.10.1997, p. 1101-1104.

Research output: Contribution to journalArticle

Goldsmith, RL, Bigger, JT, Bloomfield, DM, Krum, H, Steinman, RC, Sackner-Bernstein, J & Packer, M 1997, 'Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure', American Journal of Cardiology, vol. 80, no. 8, pp. 1101-1104. https://doi.org/10.1016/S0002-9149(97)00616-4
Goldsmith, Rochelle L. ; Bigger, J. Thomas ; Bloomfield, Daniel M. ; Krum, Henry ; Steinman, Richard C. ; Sackner-Bernstein, Jonathan ; Packer, Milton. / Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure. In: American Journal of Cardiology. 1997 ; Vol. 80, No. 8. pp. 1101-1104.
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