Abstract
Synthesis of cholesterol was measured in a familial hypercholesterolemia homozygote on four occasions from age 1.1 to 9.9 years by the sterol balance technique. Both the fecal neutral steroid and fecal bile acid components of sterol balance were elevated initially. Over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion/kg was unchanged. Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 415-418 |
| Number of pages | 4 |
| Journal | Metabolism |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote. / Levy, Richard A.; Ostlund, Richard E.; Goldberg, Anne C.; Grundy, Scott M.
In: Metabolism, Vol. 35, No. 5, 1986, p. 415-418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote
AU - Levy, Richard A.
AU - Ostlund, Richard E.
AU - Goldberg, Anne C.
AU - Grundy, Scott M
PY - 1986
Y1 - 1986
N2 - Synthesis of cholesterol was measured in a familial hypercholesterolemia homozygote on four occasions from age 1.1 to 9.9 years by the sterol balance technique. Both the fecal neutral steroid and fecal bile acid components of sterol balance were elevated initially. Over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion/kg was unchanged. Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis.
AB - Synthesis of cholesterol was measured in a familial hypercholesterolemia homozygote on four occasions from age 1.1 to 9.9 years by the sterol balance technique. Both the fecal neutral steroid and fecal bile acid components of sterol balance were elevated initially. Over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion/kg was unchanged. Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis.
UR - http://www.scopus.com/inward/record.url?scp=0022446588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022446588&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(86)90130-7
DO - 10.1016/0026-0495(86)90130-7
M3 - Article
VL - 35
SP - 415
EP - 418
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 5
ER -