Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote

Richard A. Levy, Richard E. Ostlund, Anne C. Goldberg, Scott M Grundy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Synthesis of cholesterol was measured in a familial hypercholesterolemia homozygote on four occasions from age 1.1 to 9.9 years by the sterol balance technique. Both the fecal neutral steroid and fecal bile acid components of sterol balance were elevated initially. Over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion/kg was unchanged. Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalMetabolism
Volume35
Issue number5
DOIs
StatePublished - 1986

Fingerprint

Plasmapheresis
Homozygote
Sterols
Hypercholesterolemia
Bile Acids and Salts
Steroids
Cholesterol
Hyperlipoproteinemia Type II
LDL Cholesterol
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote. / Levy, Richard A.; Ostlund, Richard E.; Goldberg, Anne C.; Grundy, Scott M.

In: Metabolism, Vol. 35, No. 5, 1986, p. 415-418.

Research output: Contribution to journalArticle

Levy, Richard A. ; Ostlund, Richard E. ; Goldberg, Anne C. ; Grundy, Scott M. / Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote. In: Metabolism. 1986 ; Vol. 35, No. 5. pp. 415-418.
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