@article{58b436dbdf2d44e49321c5db2af1245e,
title = "Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote",
abstract = "Synthesis of cholesterol was measured in a familial hypercholesterolemia homozygote on four occasions from age 1.1 to 9.9 years by the sterol balance technique. Both the fecal neutral steroid and fecal bile acid components of sterol balance were elevated initially. Over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion/kg was unchanged. Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis.",
author = "Levy, {Richard A.} and Ostlund, {Richard E.} and Goldberg, {Anne C.} and Grundy, {Scott M}",
note = "Funding Information: From the Washington University School of Medicine, Metabp lism Division, Department of Medicine,S t Louis and the Centerfor Human Nutrition, Univerity of Texas Health Science Center, Dallas. Supported by NIH grants ROI HL29229, ROl HL29252. the Veterans Administration, and the General Clinical Research Centers program. Address reprint requests to Richard E. Ostlund. MD, Washington University School of Medicine. Metabolism Division, Department of Medicine, 660 South Euclid Ave, St. Louis, MO 631 IO. o 1986 by Grune & Stratton, Inc. 0026-0495j86/3505~007$03.00/0",
year = "1986",
month = may,
doi = "10.1016/0026-0495(86)90130-7",
language = "English (US)",
volume = "35",
pages = "415--418",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "5",
}