Long-Term Cognitive Sequelae of Acyclovir-Treated Herpes Simplex Encephalitis

B. Gordon, O. A. Selnes, J. Hart, D. F. Hanley, R. J. Whitley

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Survival from untreated herpes simplex type 1 encephalitis is well known to be accompanied by severe cognitive impairments. Recently, acyclovir has been proven to be the most effective available treatment for this disease, with the expectation that it would appreciably reduce morbidity. We performed detailed assessments of four consecutive patients who received acyclovir in the early stages of biopsy-proven herpes encephalitis and who now have been followed up for 1.5 to 4 years. All four patients showed definite residual on either clinical or formal neuropsychological testing, most commonly dysnomia and impaired new learning for both verbal and visual material, even though three had normal performance on a standard clinical mental status test. All four patients were unable to function at their prior level of achievement. Therefore, despite early administration of acyclovir in herpes encephalitis, long-lasting neuropsychological residua are likely. Furthermore, cognitive deficits of prognostic importance may not be detected by clinical screening.

Original languageEnglish (US)
Pages (from-to)646-647
Number of pages2
JournalArchives of neurology
Volume47
Issue number6
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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