Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection

Barbara Haber, Estella Alonso, Alejandra Pedreira, Norberto Rodriguez-Baez, Mirta Ciocca, Florence Lacaille, Thomas Lang, Teresita Gonzalez, Zachary Goodman, Zijiang Yang, Beth Jackson, Stephanie Noviello, Janice K. Albrecht

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES:: To describe the 5-year follow-up of children who received peginterferon and ribavirin in a global, open-label study. METHODS:: A 5-year follow-up study of 107 children and adolescents aged 3–17 years with chronic hepatitis C virus infection who received peginterferon and ribavirin for 24 or 48 weeks. No drugs were administered during follow-up. RESULTS:: Ninety-four patients were enrolled in the long-term follow-up portion of the study; the median duration of follow-up was 287 weeks (range, 73–339). Of 63 patients with sustained virologic response who were enrolled, 54 completed 5 years of follow-up; none had relapse in the 5-year follow-up period. Significant decreases in height z scores were observed during treatment. The impact of treatment on height z score was larger in patients treated for 48 weeks compared with those treated for 24 weeks (mean change from baseline to the end of treatment was -0.13 (p?

Original languageEnglish (US)
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
StateAccepted/In press - Apr 21 2016

Fingerprint

Ribavirin
Virus Diseases
Hepacivirus
Chronic Hepatitis C
Therapeutics
Recurrence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection. / Haber, Barbara; Alonso, Estella; Pedreira, Alejandra; Rodriguez-Baez, Norberto; Ciocca, Mirta; Lacaille, Florence; Lang, Thomas; Gonzalez, Teresita; Goodman, Zachary; Yang, Zijiang; Jackson, Beth; Noviello, Stephanie; Albrecht, Janice K.

In: Journal of Pediatric Gastroenterology and Nutrition, 21.04.2016.

Research output: Contribution to journalArticle

Haber, B, Alonso, E, Pedreira, A, Rodriguez-Baez, N, Ciocca, M, Lacaille, F, Lang, T, Gonzalez, T, Goodman, Z, Yang, Z, Jackson, B, Noviello, S & Albrecht, JK 2016, 'Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection', Journal of Pediatric Gastroenterology and Nutrition. https://doi.org/10.1097/MPG.0000000000001239
Haber, Barbara ; Alonso, Estella ; Pedreira, Alejandra ; Rodriguez-Baez, Norberto ; Ciocca, Mirta ; Lacaille, Florence ; Lang, Thomas ; Gonzalez, Teresita ; Goodman, Zachary ; Yang, Zijiang ; Jackson, Beth ; Noviello, Stephanie ; Albrecht, Janice K. / Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection. In: Journal of Pediatric Gastroenterology and Nutrition. 2016.
@article{3acd632af2254f6a81452044288b6a15,
title = "Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection",
abstract = "OBJECTIVES:: To describe the 5-year follow-up of children who received peginterferon and ribavirin in a global, open-label study. METHODS:: A 5-year follow-up study of 107 children and adolescents aged 3–17 years with chronic hepatitis C virus infection who received peginterferon and ribavirin for 24 or 48 weeks. No drugs were administered during follow-up. RESULTS:: Ninety-four patients were enrolled in the long-term follow-up portion of the study; the median duration of follow-up was 287 weeks (range, 73–339). Of 63 patients with sustained virologic response who were enrolled, 54 completed 5 years of follow-up; none had relapse in the 5-year follow-up period. Significant decreases in height z scores were observed during treatment. The impact of treatment on height z score was larger in patients treated for 48 weeks compared with those treated for 24 weeks (mean change from baseline to the end of treatment was -0.13 (p?",
author = "Barbara Haber and Estella Alonso and Alejandra Pedreira and Norberto Rodriguez-Baez and Mirta Ciocca and Florence Lacaille and Thomas Lang and Teresita Gonzalez and Zachary Goodman and Zijiang Yang and Beth Jackson and Stephanie Noviello and Albrecht, {Janice K.}",
year = "2016",
month = "4",
day = "21",
doi = "10.1097/MPG.0000000000001239",
language = "English (US)",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Long-term Follow-up of Children Treated With Peginterferon and Ribavirin for Hepatitis C Virus Infection

AU - Haber, Barbara

AU - Alonso, Estella

AU - Pedreira, Alejandra

AU - Rodriguez-Baez, Norberto

AU - Ciocca, Mirta

AU - Lacaille, Florence

AU - Lang, Thomas

AU - Gonzalez, Teresita

AU - Goodman, Zachary

AU - Yang, Zijiang

AU - Jackson, Beth

AU - Noviello, Stephanie

AU - Albrecht, Janice K.

PY - 2016/4/21

Y1 - 2016/4/21

N2 - OBJECTIVES:: To describe the 5-year follow-up of children who received peginterferon and ribavirin in a global, open-label study. METHODS:: A 5-year follow-up study of 107 children and adolescents aged 3–17 years with chronic hepatitis C virus infection who received peginterferon and ribavirin for 24 or 48 weeks. No drugs were administered during follow-up. RESULTS:: Ninety-four patients were enrolled in the long-term follow-up portion of the study; the median duration of follow-up was 287 weeks (range, 73–339). Of 63 patients with sustained virologic response who were enrolled, 54 completed 5 years of follow-up; none had relapse in the 5-year follow-up period. Significant decreases in height z scores were observed during treatment. The impact of treatment on height z score was larger in patients treated for 48 weeks compared with those treated for 24 weeks (mean change from baseline to the end of treatment was -0.13 (p?

AB - OBJECTIVES:: To describe the 5-year follow-up of children who received peginterferon and ribavirin in a global, open-label study. METHODS:: A 5-year follow-up study of 107 children and adolescents aged 3–17 years with chronic hepatitis C virus infection who received peginterferon and ribavirin for 24 or 48 weeks. No drugs were administered during follow-up. RESULTS:: Ninety-four patients were enrolled in the long-term follow-up portion of the study; the median duration of follow-up was 287 weeks (range, 73–339). Of 63 patients with sustained virologic response who were enrolled, 54 completed 5 years of follow-up; none had relapse in the 5-year follow-up period. Significant decreases in height z scores were observed during treatment. The impact of treatment on height z score was larger in patients treated for 48 weeks compared with those treated for 24 weeks (mean change from baseline to the end of treatment was -0.13 (p?

UR - http://www.scopus.com/inward/record.url?scp=84964292289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964292289&partnerID=8YFLogxK

U2 - 10.1097/MPG.0000000000001239

DO - 10.1097/MPG.0000000000001239

M3 - Article

C2 - 27111344

AN - SCOPUS:84964292289

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

ER -