Long-term outcomes in treatment of retroperitoneal sarcomas

A 15 year single-institution evaluation of prognostic features

Eihab Abdelfatah, Angela A. Guzzetta, Neeraja Nagarajan, Christopher L. Wolfgang, Timothy M. Pawlik, Michael A. Choti, Richard Schulick, Elizabeth A. Montgomery, Christian Meyer, Katherine Thornton, Joseph Herman, Stephanie Terezakis, Deborah Frassica, Nita Ahuja

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Retroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution's experience to evaluate prognostic factors. Methods: Retrospective chart review of all primary RPS patients at Johns Hopkins Hospital from 1994 to 2010. Histologic diagnosis and grading were re-evaluated with current criteria. Prognostic factors for survival, and recurrence were assessed. Results: One hundred thirty-one primary RPS patients met inclusion criteria. Median survival for patients who undergo en-bloc resection to negative margins (R0/R1) is 81.7 months. Surgical margins and grade were the most important factors for survival along with age, gender, presence of metastases and resection of ≥5 organs. Five-year survival for R0/R1 resection was 60%, similar to compartmental resection. Radiotherapy significantly decreased local recurrence (P = 0.026) on multivariate analysis. Grade in leiomyosarcomas and dedifferentiation in liposarcomas dictated patterns of local versus distal recurrence. Conclusions: En bloc surgical resection to R0/R1 margins remains the cornerstone of therapy and provides comparable outcomes to compartmental resections. Grade remains important for prognosis, and histology dictates recurrence patterns. Radiotherapy appears promising for local control and warrants further investigation. J. Surg. Oncol. 2016;114:56–64.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalJournal of Surgical Oncology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2016

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Sarcoma
Recurrence
Radiotherapy
Survival
Liposarcoma
Leiomyosarcoma
Connective Tissue
Histology
Multivariate Analysis
Neoplasm Metastasis
Therapeutics
Neoplasms

Keywords

  • compartmental resection
  • grade
  • leiomyosarcoma
  • liposarcoma
  • radiation
  • sarcoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Long-term outcomes in treatment of retroperitoneal sarcomas : A 15 year single-institution evaluation of prognostic features. / Abdelfatah, Eihab; Guzzetta, Angela A.; Nagarajan, Neeraja; Wolfgang, Christopher L.; Pawlik, Timothy M.; Choti, Michael A.; Schulick, Richard; Montgomery, Elizabeth A.; Meyer, Christian; Thornton, Katherine; Herman, Joseph; Terezakis, Stephanie; Frassica, Deborah; Ahuja, Nita.

In: Journal of Surgical Oncology, Vol. 114, No. 1, 01.07.2016, p. 56-64.

Research output: Contribution to journalArticle

Abdelfatah, E, Guzzetta, AA, Nagarajan, N, Wolfgang, CL, Pawlik, TM, Choti, MA, Schulick, R, Montgomery, EA, Meyer, C, Thornton, K, Herman, J, Terezakis, S, Frassica, D & Ahuja, N 2016, 'Long-term outcomes in treatment of retroperitoneal sarcomas: A 15 year single-institution evaluation of prognostic features', Journal of Surgical Oncology, vol. 114, no. 1, pp. 56-64. https://doi.org/10.1002/jso.24256
Abdelfatah, Eihab ; Guzzetta, Angela A. ; Nagarajan, Neeraja ; Wolfgang, Christopher L. ; Pawlik, Timothy M. ; Choti, Michael A. ; Schulick, Richard ; Montgomery, Elizabeth A. ; Meyer, Christian ; Thornton, Katherine ; Herman, Joseph ; Terezakis, Stephanie ; Frassica, Deborah ; Ahuja, Nita. / Long-term outcomes in treatment of retroperitoneal sarcomas : A 15 year single-institution evaluation of prognostic features. In: Journal of Surgical Oncology. 2016 ; Vol. 114, No. 1. pp. 56-64.
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AU - Choti, Michael A.

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AU - Montgomery, Elizabeth A.

AU - Meyer, Christian

AU - Thornton, Katherine

AU - Herman, Joseph

AU - Terezakis, Stephanie

AU - Frassica, Deborah

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