Long-term potentiation and 4-aminopyridine

H. L. Haas, R. W. Greene

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. 2. In the presence of 100 μM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from normal. 3. During LTP saturation, 4-AP further enhanced the epsp. 4. These data are inconsistent with an involvement of A-current reduction in LTP.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalCellular and Molecular Neurobiology
Volume5
Issue number3
DOIs
StatePublished - Sep 1985

Fingerprint

4-Aminopyridine
Long-Term Potentiation
Rats
Excitatory Postsynaptic Potentials

Keywords

  • 4-aminopyridine
  • hippocampal slice
  • long-term potentiation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Long-term potentiation and 4-aminopyridine. / Haas, H. L.; Greene, R. W.

In: Cellular and Molecular Neurobiology, Vol. 5, No. 3, 09.1985, p. 297-301.

Research output: Contribution to journalArticle

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