Long-term potentiation and 4-aminopyridine

H. L. Haas, R. W. Greene

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

1. Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. 2. In the presence of 100 μM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from normal. 3. During LTP saturation, 4-AP further enhanced the epsp. 4. These data are inconsistent with an involvement of A-current reduction in LTP.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalCellular and Molecular Neurobiology
Volume5
Issue number3
DOIs
StatePublished - Sep 1 1985

Keywords

  • 4-aminopyridine
  • hippocampal slice
  • long-term potentiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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