Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors

Woo Ping Ge, Xiu Juan Yang, Zhijun Zhang, Hui Kun Wang, Wanhua Shen, Qiu Dong Deng, Shumin Duan

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells.

Original languageEnglish (US)
Pages (from-to)1533-1537
Number of pages5
JournalScience
Volume312
Issue number5779
DOIs
StatePublished - Jun 9 2006

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AMPA Receptors
Long-Term Potentiation
Neuroglia
Synapses
Neurons
Neuronal Plasticity
Brain
(2-azidomethyl)phenylacetyl
Synaptic Transmission
Maintenance
Population

ASJC Scopus subject areas

  • General

Cite this

Ge, W. P., Yang, X. J., Zhang, Z., Wang, H. K., Shen, W., Deng, Q. D., & Duan, S. (2006). Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors. Science, 312(5779), 1533-1537. https://doi.org/10.1126/science.1124669

Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors. / Ge, Woo Ping; Yang, Xiu Juan; Zhang, Zhijun; Wang, Hui Kun; Shen, Wanhua; Deng, Qiu Dong; Duan, Shumin.

In: Science, Vol. 312, No. 5779, 09.06.2006, p. 1533-1537.

Research output: Contribution to journalArticle

Ge, WP, Yang, XJ, Zhang, Z, Wang, HK, Shen, W, Deng, QD & Duan, S 2006, 'Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors', Science, vol. 312, no. 5779, pp. 1533-1537. https://doi.org/10.1126/science.1124669
Ge, Woo Ping ; Yang, Xiu Juan ; Zhang, Zhijun ; Wang, Hui Kun ; Shen, Wanhua ; Deng, Qiu Dong ; Duan, Shumin. / Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors. In: Science. 2006 ; Vol. 312, No. 5779. pp. 1533-1537.
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