Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors

Woo Ping Ge, Xiu Juan Yang, Zhijun Zhang, Hui Kun Wang, Wanhua Shen, Qiu Dong Deng, Shumin Duan

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Abstract

Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells.

Original languageEnglish (US)
Pages (from-to)1533-1537
Number of pages5
JournalScience
Volume312
Issue number5779
DOIs
StatePublished - Jun 9 2006

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Cite this

Ge, W. P., Yang, X. J., Zhang, Z., Wang, H. K., Shen, W., Deng, Q. D., & Duan, S. (2006). Long-term potentiation of neuron-glia synapses mediated by Ca 2+-permeable AMPA receptors. Science, 312(5779), 1533-1537. https://doi.org/10.1126/science.1124669