Long-term survival after radical operations for cancer treatment-induced sarcomas: How two survivors invite reflection on oncologic treatment concepts

Roderich E. Schwarz, Georg Hillebrand, Elizabeth A. Peralta, David Z J Chu, Lawrence M. Weiss

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Extent and radicality of surgical oncologic treatment has changed in the past 30 years. Two patients with node-positive breast cancer are presented, who underwent (total or radical) mastectomy with lymphadenectomy and postoperative radiation 24 and 40 years ago. A radiation-associated sarcoma of the parascapular soft tissue developed in one patient 9 years after treatment; the other one sought treatment for a lymphedema-associated Stewart-Treves lymphangiosarcoma 16 years after initial therapy. Both patients underwent a forequarter amputation for their treatment-associated high-grade sarcoma. Both are currently alive and cancer-free 15 and 24 years after amputation. These reports remind us that radical locoregional treatment can cure some solid cancers in the absence of systemic therapy; that such extensive treatment may induce significant disability or secondary malignancies long-term; that even advanced treatment-associated sarcomas can be cured with aggressive resection; that today's multimodality therapy approaches and appropriate patient selection have rendered such extensive locoregional treatment for many tumors obsolete or unnecessary; and that if no effective alternative treatment exists and organ or limb preservation is not feasible, an aggressive resection approach for high-grade cancer should not be discounted unless systemic failure is certain or imminent.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume25
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Sarcoma
Survivors
Survival
Neoplasms
Therapeutics
Amputation
Lymphangiosarcoma
Radiation
Radical Mastectomy
Lymphedema
Lymph Node Excision
Patient Selection
Extremities
Breast Neoplasms

Keywords

  • Radical resections
  • Sarcomas, treatment-induced

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Long-term survival after radical operations for cancer treatment-induced sarcomas : How two survivors invite reflection on oncologic treatment concepts. / Schwarz, Roderich E.; Hillebrand, Georg; Peralta, Elizabeth A.; Chu, David Z J; Weiss, Lawrence M.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 25, No. 3, 2002, p. 244-247.

Research output: Contribution to journalArticle

Schwarz, Roderich E. ; Hillebrand, Georg ; Peralta, Elizabeth A. ; Chu, David Z J ; Weiss, Lawrence M. / Long-term survival after radical operations for cancer treatment-induced sarcomas : How two survivors invite reflection on oncologic treatment concepts. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2002 ; Vol. 25, No. 3. pp. 244-247.
@article{bbe0dd2f749547ecb6ff9d4bec2ec2e5,
title = "Long-term survival after radical operations for cancer treatment-induced sarcomas: How two survivors invite reflection on oncologic treatment concepts",
abstract = "Extent and radicality of surgical oncologic treatment has changed in the past 30 years. Two patients with node-positive breast cancer are presented, who underwent (total or radical) mastectomy with lymphadenectomy and postoperative radiation 24 and 40 years ago. A radiation-associated sarcoma of the parascapular soft tissue developed in one patient 9 years after treatment; the other one sought treatment for a lymphedema-associated Stewart-Treves lymphangiosarcoma 16 years after initial therapy. Both patients underwent a forequarter amputation for their treatment-associated high-grade sarcoma. Both are currently alive and cancer-free 15 and 24 years after amputation. These reports remind us that radical locoregional treatment can cure some solid cancers in the absence of systemic therapy; that such extensive treatment may induce significant disability or secondary malignancies long-term; that even advanced treatment-associated sarcomas can be cured with aggressive resection; that today's multimodality therapy approaches and appropriate patient selection have rendered such extensive locoregional treatment for many tumors obsolete or unnecessary; and that if no effective alternative treatment exists and organ or limb preservation is not feasible, an aggressive resection approach for high-grade cancer should not be discounted unless systemic failure is certain or imminent.",
keywords = "Radical resections, Sarcomas, treatment-induced",
author = "Schwarz, {Roderich E.} and Georg Hillebrand and Peralta, {Elizabeth A.} and Chu, {David Z J} and Weiss, {Lawrence M.}",
year = "2002",
doi = "10.1097/00000421-200206000-00008",
language = "English (US)",
volume = "25",
pages = "244--247",
journal = "American Journal of Clinical Oncology",
issn = "0277-3732",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Long-term survival after radical operations for cancer treatment-induced sarcomas

T2 - How two survivors invite reflection on oncologic treatment concepts

AU - Schwarz, Roderich E.

AU - Hillebrand, Georg

AU - Peralta, Elizabeth A.

AU - Chu, David Z J

AU - Weiss, Lawrence M.

PY - 2002

Y1 - 2002

N2 - Extent and radicality of surgical oncologic treatment has changed in the past 30 years. Two patients with node-positive breast cancer are presented, who underwent (total or radical) mastectomy with lymphadenectomy and postoperative radiation 24 and 40 years ago. A radiation-associated sarcoma of the parascapular soft tissue developed in one patient 9 years after treatment; the other one sought treatment for a lymphedema-associated Stewart-Treves lymphangiosarcoma 16 years after initial therapy. Both patients underwent a forequarter amputation for their treatment-associated high-grade sarcoma. Both are currently alive and cancer-free 15 and 24 years after amputation. These reports remind us that radical locoregional treatment can cure some solid cancers in the absence of systemic therapy; that such extensive treatment may induce significant disability or secondary malignancies long-term; that even advanced treatment-associated sarcomas can be cured with aggressive resection; that today's multimodality therapy approaches and appropriate patient selection have rendered such extensive locoregional treatment for many tumors obsolete or unnecessary; and that if no effective alternative treatment exists and organ or limb preservation is not feasible, an aggressive resection approach for high-grade cancer should not be discounted unless systemic failure is certain or imminent.

AB - Extent and radicality of surgical oncologic treatment has changed in the past 30 years. Two patients with node-positive breast cancer are presented, who underwent (total or radical) mastectomy with lymphadenectomy and postoperative radiation 24 and 40 years ago. A radiation-associated sarcoma of the parascapular soft tissue developed in one patient 9 years after treatment; the other one sought treatment for a lymphedema-associated Stewart-Treves lymphangiosarcoma 16 years after initial therapy. Both patients underwent a forequarter amputation for their treatment-associated high-grade sarcoma. Both are currently alive and cancer-free 15 and 24 years after amputation. These reports remind us that radical locoregional treatment can cure some solid cancers in the absence of systemic therapy; that such extensive treatment may induce significant disability or secondary malignancies long-term; that even advanced treatment-associated sarcomas can be cured with aggressive resection; that today's multimodality therapy approaches and appropriate patient selection have rendered such extensive locoregional treatment for many tumors obsolete or unnecessary; and that if no effective alternative treatment exists and organ or limb preservation is not feasible, an aggressive resection approach for high-grade cancer should not be discounted unless systemic failure is certain or imminent.

KW - Radical resections

KW - Sarcomas, treatment-induced

UR - http://www.scopus.com/inward/record.url?scp=0036271839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036271839&partnerID=8YFLogxK

U2 - 10.1097/00000421-200206000-00008

DO - 10.1097/00000421-200206000-00008

M3 - Article

C2 - 12040281

AN - SCOPUS:0036271839

VL - 25

SP - 244

EP - 247

JO - American Journal of Clinical Oncology

JF - American Journal of Clinical Oncology

SN - 0277-3732

IS - 3

ER -