Long-term survival outcomes of triple-receptor negative breast cancer survivors who are disease free at 5 years and relationship with low hormone receptor positivity

S. M. Reddy, C. H. Barcenas, A. K. Sinha, L. Hsu, S. L. Moulder, D. Tripathy, G. N. Hortobagyi, V. Valero

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background:We counsel our triple-negative breast cancer (TNBC) patients that the risk of recurrence is highest in the first 5 years after diagnosis. However, there are limited data with extended follow-up on the frequency, characteristics, and predictors of late events.Methods:We queried the MD Anderson Breast Cancer Management System database to identify patients with stage I-III TNBC who were disease free at 5 years from diagnosis. The Kaplan-Meier method was used to estimate yearly recurrence-free interval (RFI), recurrence-free survival (RFS), and distant relapse-free survival (DRFS), as defined by the STEEP criteria. Cox proportional hazards model was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs).Results:We identified 873 patients who were disease free at least 5 years from diagnosis with median follow-up of 8.3 years. The 10-year RFI was 97%, RFS 91%, and DRFS 92%; the 15-year RFI was 95%, RFS 83%, and DRFS 84%. On a subset of patients with oestrogen receptor and progesterone receptor percentage recorded, low hormone receptor positivity conferred higher risk of late events on multivariable analysis for RFS only (RFI: HR=1.98, 95% CI=0.70-5.62, P-value=0.200; RFS: HR=1.94, 95% CI=1.05-3.56, P-value=0.034; DRFS: HR=1.72, 95% CI=0.92-3.24, P-value=0.091).Conclusions:The TNBC survivors who have been disease free for 5 years have a low probability of experiencing recurrence over the subsequent 10 years. Patients with low hormone receptor-positive cancers may have a higher risk of late events as measured by RFS but not by RFI or DRFS.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalBritish journal of cancer
Volume118
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • breast cancer
  • hormone receptor
  • recurrence
  • survivors
  • survivorship
  • triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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