Long-term therapy for pulmonary hypertension in children

Catherine L. Dent, J. Julio Pérez Fontán

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

This review recounts recent advances in the understanding and treatment of the processes that cause pulmonary hypertension in infancy and childhood. New discoveries have begun to unveil connections between the basic physiological mechanisms responsible for the regulation of pulmonary vascular tone and the abnormal responses of the pulmonary vasculature in a variety of disease conditions, These discoveries raise hope for new therapeutic interventions that may improve the high mortality and morbidity of both children and adults with pulmonary vascular disease. In the meantime, treatment efforts continue to be focused on the relief of pulmonary vasoconstriction with inhaled nitric oxide and intravenous prostacyclin in the short term and oral calcium channel blockers as the mainstay of long-term therapy. Lung transplantation often remains as the only viable option for continued survival when the pulmonary vascular disease is progressive.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalCurrent opinion in pediatrics
Volume11
Issue number3
DOIs
StatePublished - Jun 10 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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