TY - JOUR
T1 - Longitudinal changes in blood-based biomarkers in chronic moderate to severe traumatic brain injury
T2 - preliminary findings
AU - Schnakers, Caroline
AU - Divine, James
AU - Johnson, Micah A.
AU - Lutkenhoff, Evan
AU - Monti, Martin M.
AU - Keil, Katrina M.
AU - Guthrie, John
AU - Pouratian, Nader
AU - Patterson, David
AU - Jensen, Gary
AU - Morales, Vanessa C.
AU - Weaver, Kathleen F.
AU - Rosario, Emily R.
N1 - Publisher Copyright:
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Objectives: This longitudinal study aims at 1) providing preliminary evidence of changes in blood-based biomarkers across time in chronic TBI and 2) relating these changes to outcome measures and cerebral structure and activity. Methods: Eight patients with moderate-to-severe TBI (7 males, 35 ± 7.6 years old, 5 severe TBI, 17.52 ± 3.84 months post-injury) were evaluated at monthly intervals across 6 time-points using: a) Blood-based biomarkers (GFAP, NSE, S100A12, SDBP145, UCH-L1, T-tau, P-tau, P-tau/T-tau ratio); b) Magnetic Resonance Imaging to evaluate changes in brain structure; c) Resting-state electroencephalograms to evaluate changes in brain function; and d) Outcome measures to assess cognition, emotion, and functional recovery (MOCA, RBANS, BDI-II, and DRS). Results: Changes in P-tau levels were found across time [p = .007]. P-tau was positively related to functional [p < .001] and cognitive [p = .006] outcomes, and negatively related to the severity of depression, 6 months later [R = −0.901; p =.006]. P-tau and P-tau/T-tau ratio were also positively correlated to shape change in subcortical areas such as brainstem [T(7) = 4.71, p = .008] and putamen [T(7) = 3.25, p = .012]. Conclusions: Our study provides preliminary findings that suggest a positive relationship between P-tau and the recovery of patients with chronic TBI.
AB - Objectives: This longitudinal study aims at 1) providing preliminary evidence of changes in blood-based biomarkers across time in chronic TBI and 2) relating these changes to outcome measures and cerebral structure and activity. Methods: Eight patients with moderate-to-severe TBI (7 males, 35 ± 7.6 years old, 5 severe TBI, 17.52 ± 3.84 months post-injury) were evaluated at monthly intervals across 6 time-points using: a) Blood-based biomarkers (GFAP, NSE, S100A12, SDBP145, UCH-L1, T-tau, P-tau, P-tau/T-tau ratio); b) Magnetic Resonance Imaging to evaluate changes in brain structure; c) Resting-state electroencephalograms to evaluate changes in brain function; and d) Outcome measures to assess cognition, emotion, and functional recovery (MOCA, RBANS, BDI-II, and DRS). Results: Changes in P-tau levels were found across time [p = .007]. P-tau was positively related to functional [p < .001] and cognitive [p = .006] outcomes, and negatively related to the severity of depression, 6 months later [R = −0.901; p =.006]. P-tau and P-tau/T-tau ratio were also positively correlated to shape change in subcortical areas such as brainstem [T(7) = 4.71, p = .008] and putamen [T(7) = 3.25, p = .012]. Conclusions: Our study provides preliminary findings that suggest a positive relationship between P-tau and the recovery of patients with chronic TBI.
KW - P-tau
KW - Traumatic brain injury
KW - blood biomarkers
KW - chronic disease
UR - http://www.scopus.com/inward/record.url?scp=85099606515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099606515&partnerID=8YFLogxK
U2 - 10.1080/02699052.2020.1858345
DO - 10.1080/02699052.2020.1858345
M3 - Article
C2 - 33461331
AN - SCOPUS:85099606515
SN - 0269-9052
VL - 35
SP - 285
EP - 291
JO - Brain injury
JF - Brain injury
IS - 3
ER -